Which of these brands scored highest overall?

Thorne averaged 85.6/100 across 7 scored products — the highest of the 2 brands compared. Higher-scoring brands generally combine full ingredient dose disclosure, formulation choices backed by RCT evidence at studied doses, and public third-party testing.

Is Thorne better than Nature Made?

On our 6-dimension rubric, yes — Thorne averaged 85.6/100 across 7 scored products versus Nature Made's 68/100 across 26 products, a 17.6-point gap. The gap comes primarily from evidence quality, dose disclosure, and formulation choices — see the per-brand deep-dive for the specific products driving each brand's average.

What is the highest-scoring Thorne product on Vyvata?

Thorne Basic Nutrients 2/Day scores 89/100 (Elite tier) — the top-scored Thorne product in our catalog. Full breakdown on the product page.

Does Nature Made have any Rejected products?

Yes — 1 of 26 scored Nature Made products hit an auto-fail rule (proprietary blend, sub-therapeutic dose, unverified claim, or outside the supplement rubric). Rejected products stay listed with reasons — see the deep-dive.

Do third-party certifications like NSF and USP guarantee a high score?

They're a strong signal on manufacturing integrity but only cover part of the Vyvata rubric. A product can be NSF-certified and still have weak evidence for its active ingredient, sub-therapeutic dosing, or misleading marketing. NSF/USP is one input into the Manufacturing dimension; the other five dimensions are independent.

Is this comparison biased by which products Vyvata carries?

Yes, in the sense that we only score products we list. We list products across all 2 brands compared here, but a brand with a wider catalog we carry can look "better" purely from statistical mass. The individual per-product scores are independent — see the deep dives above for the specific products and reasoning per brand.

How often does this comparison update?

Whenever any of these brands' products get rescored. New evidence (published trials, third-party testing releases, label updates) can shift individual products up or down, which changes the brand averages. Every score carries a "last scored" timestamp on the product page.

Brand comparison

Thorne vs Nature Made: Practitioner-Tier vs Pharmacy-Shelf, Scored Head-to-Head

By the Vyvata Scoring Team · Updated October 6, 2026

Nature Made is the #1 pharmacist-recommended vitamin brand in the US, built on USP Verified certification and decades of pharmacy-shelf presence. Thorne is the practitioner-channel brand P&G just paid $3.8 billion for. Both lean on third-party certification as a quality signal — USP for Nature Made, NSF Certified for Sport for Thorne. Certifications are a floor, not a ranking. Here's how every scored product from each brand actually performs on the Vyvata 6-dimension rubric. Read the rubric →

Head-to-head summary

#	Brand	Avg score	Scored	Tier mix	Top product
1	Thorne	85.6	7 of 7	6 Elite 1 Verified	Thorne Basic Nutrients 2/Day · 89
2	Nature Made	68	26 of 26	13 Verified 12 Standard 1 Rejected	Nature Made Vitamin C 500 Mg Caplets With Rose Hips - 130ct · 78

Overall winner on average score: Thorne at 85.6/100 across 7 scored products.

Per-brand deep dive

Thorneavg 85.6/100 across 7 scored products

Thorne Basic Nutrients 2/Day 89/100 · Elite

Foundational multi built on active B-vitamin forms (5-MTHF folate, methylcobalamin, P-5-P B6) and chelated minerals — the anchor product for the Elite tier.
Thorne Methyl-Guard Plus Dietary Supplement, 90 Capsules EXP 10/2026 88/100 · Elite

[Rescored via evidence crawl] Previous score 84 → new 88.
Thorne Selenium 200 mcg Dietary Supplement EXP 7/2027 87/100 · Elite

Genuine Thorne Selenium 200 mcg as selenomethionine (highly bioavailable form).
Thorne Creatine Monohydrate 85/100 · Elite

[Rescored via evidence crawl] Previous score 78 → new 85.
Thorne Magnesium Bisglycinate 85/100 · Elite

[Rescored via evidence crawl] Previous score 81 → new 85.

Nature Madeavg 68/100 across 26 scored products

Nature Made Vitamin C 500 Mg Caplets With Rose Hips - 130ct 78/100 · Verified

Nature Made is a well-established, USP Verified vitamin brand, and 500mg of vitamin C is a standard, well-studied supplementation dose for immune and antioxidant support.
Nature Made Vitamin D3 2000 IU 76/100 · Verified

2000 IU vitamin D3 (cholecalciferol) softgel.
Nature Made Vitamin D3 1000 IU 100 Tablets 25 Mcg 76/100 · Verified

Nature Made Vitamin D3 1000 IU is USP-Verified — one of the strongest independent quality seals in the OTC supplement space, confirming label accuracy, purity and manufacturing controls. Standard supportive D3 dose backed by extensive population evidence.
Nature Made Co Q10, 200 Mg, Softgels, Value Size 73/100 · Verified

Nature Made CoQ10 200 mg ubiquinone softgel.
Nature Made CoQ10 100 Mg With Black Pepper Extract Softgels 73/100 · Verified

Nature Made CoQ10 100 mg ubiquinone softgel with black-pepper (piperine) extract.

How the scoring works

Every product is scored on six dimensions — evidence (RCT quality supporting the active ingredients at the label dose), formulation (dose adequacy, bioavailability form, redundancy), manufacturing (third-party testing, GMP, facility audits), safety (adverse-event profile, interactions, dose ceiling), transparency (dose disclosure vs proprietary blends, honest marketing), and sustainability (sourcing, packaging, corporate practice). Tier thresholds: Elite 85+, Verified 70–84, Standard 50–69, Rejected 0–49. Rejected products stay listed with reasons. Full rubric →

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