Thorne Methyl-Guard Plus Dietary Supplement, 90 Capsules EXP 10/2026
Thorne Methyl-Guard Plus Dietary Supplement, 90 Capsules EXP 10/2026
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Expiration Date: 10-2026
Package contains 90 capsules.
Methyl-Guard Plus is a dietary supplement designed to provide methylation factors.
Seal is intact.
Stored at room temperature.
The full picture
Everything Vyvata knows about this product — the score, the evidence, the FAQ, and where else to find shopper reviews. No hidden data. Every vendor is scored on the same published rubric — no brand can pay for placement. Read the rubric →
Six-dimension breakdown
Why this scored 84/100
Thorne Methyl-Guard Plus: L-5-MTHF (methylfolate), methylcobalamin B12, P5P B6, riboflavin 5'-phosphate, betaine. Evidence for homocysteine reduction (Homocysteine Lowering Trialists 2005) at these active forms. Thorne NSF-tested formulation. Just below Elite due to broader methylation stack complexity; reseller listing (near-expiry 10/2026) trims sustainability slightly. Verified anchor akin to Pure Encapsulations.
Evidence & sources
The Vyvata score's Evidence dimension measures the quality of published RCT support for a product's active ingredients at the label dose. Our source hierarchy: double-blind RCTs in MEDLINE-indexed journals > single-blind RCTs > open-label trials > observational studies > mechanism papers > N=1 case studies (anecdotes). Predatory journals and manufacturer-authored studies without independent replication are weighted down.
Product-specific evidence citations for this item are embedded in the analysis text on the "Analysis" tab. For the full framework and evidence hierarchy, see the methodology page.
How to read the Evidence dimension
- 80–100: Multiple double-blind RCTs in indexed journals directly testing this product OR the exact ingredients at the exact dose.
- 60–79: Single double-blind RCT + supporting ingredient literature at the studied dose.
- 40–59: Open-label trials + ingredient literature; no product-specific double-blind evidence.
- 20–39: Ingredient literature only; no product-specific trials or trials in predatory venues.
- 0–19: No credible evidence base or unverifiable claims.
Frequently asked questions
Auto-generated from Vyvata's scoring data for this product. For general questions about the store (shipping, returns, wholesale), see the site FAQ.
What is Thorne Methyl-Guard Plus Dietary Supplement, 90 Capsules EXP 10/2026?
Thorne Methyl-Guard Plus Dietary Supplement, 90 Capsules EXP 10/2026 is a product from Thorne, categorized under Vitamins & foundational micronutrients in the Supplements vertical. It is scored on the Vyvata Scoring Framework — an independent 6-dimension rubric applied uniformly to every product Vyvata lists.
How does Thorne Methyl-Guard Plus Dietary Supplement, 90 Capsules EXP 10/2026 score on the Vyvata rubric?
84/100 overall — Verified tier (70–84 band). Per-dimension breakdown: Manufacturing 92, Transparency 88, Formulation 85, Safety 82, Evidence 80, Sustainability 70. Scored as of 2026-07-31.
Why did Thorne Methyl-Guard Plus Dietary Supplement, 90 Capsules EXP 10/2026 score in the Verified tier?
Thorne Methyl-Guard Plus: L-5-MTHF (methylfolate), methylcobalamin B12, P5P B6, riboflavin 5'-phosphate, betaine. Evidence for homocysteine reduction (Homocysteine Lowering Trialists 2005) at these active forms. Thorne NSF-tested formulation. Just below Elite due to broader methylation stack complexity; reseller listing (near-expiry 10/2026) trims sustainability slightly. Verified anchor akin to Pure Encapsulations.
What are the strongest and weakest aspects of this product?
Strongest: Manufacturing at 92/100 (third-party testing, GMP compliance, and facility audit status) and Transparency at 88/100 (dose disclosure vs proprietary blends, and honesty of marketing claims). Weakest: Evidence at 80/100 (quality of published RCT support for the active ingredients at the label dose) and Sustainability at 70/100 (sourcing practices, packaging, and corporate practice). All six dimensions feed the overall Vyvata score; a weakness on any one dimension pulls the overall down proportionally.
Is Thorne Methyl-Guard Plus Dietary Supplement, 90 Capsules EXP 10/2026 third-party tested?
No third-party certifications (NSF, USP, ConsumerLab, or equivalent) were on record at the time of scoring. This affects the Manufacturing dimension score. The manufacturer may test internally or have obtained certification more recently — check the current product label for the most up-to-date information.
Are there higher-scoring alternatives to Thorne Methyl-Guard Plus Dietary Supplement, 90 Capsules EXP 10/2026?
The top-ranked vitamins & foundational micronutrients product in the Vyvata catalog is currently Thorne Basic Nutrients 2/Day at 89/100. See the full ranked list of 222 scored products in this subcategory at https://vyvata.com/pages/best-vitamins-and-foundational-micronutrients-supplements-ranked.
What does the Vyvata score mean?
The Vyvata Scoring Framework rates every listed product 0–100 across six dimensions: Evidence, Formulation, Manufacturing, Safety, Transparency, and Sustainability. Tier bands: Elite 85–100 (top-tier evidence + formulation + manufacturing), Verified 70–84 (strong on most dimensions), Standard 50–69 (solid but with weaknesses called out), Rejected 0–49 (specific failures documented). Rejected products remain listed with reasons. Full methodology at https://vyvata.com/pages/methodology.
Where can I read customer reviews for Thorne Methyl-Guard Plus Dietary Supplement, 90 Capsules EXP 10/2026?
The Vyvata score measures product integrity against a published rubric, not customer sentiment. For customer reviews and community discussion, search external platforms directly: Amazon (https://www.amazon.com/s?k=Thorne%20Thorne%20Methyl-Guard%20Plus%20Dietary%20Supplement%2C%2090%20Capsules%20EXP%2010%2F2026),Google(https://www.google.com/search?q=Thorne%20Thorne%20Methyl-Guard%20Plus%20Dietary%20Supplement%2C%2090%20Capsules%20EXP%2010%2F2026+reviews),Reddit(https://www.reddit.com/search/?q=Thorne%20Thorne%20Methyl-Guard%20Plus%20Dietary%20Supplement%2C%2090%20Capsules%20EXP%2010%2F2026%20review),andTrustpilot(https://www.trustpilot.com/search?query=Thorne%20Thorne%20Methyl-Guard%20Plus%20Dietary%20Supplement%2C%2090%20Capsules%20EXP%2010%2F2026).Vyvatadoesnotaggregate,republish,orlicensethosethird-partyreviews.
Customer reviews
Reviews on other platforms
The Vyvata score measures product integrity against a published rubric, not customer sentiment. Vyvata does not aggregate, republish, or license third-party reviews — the links below open search pages on their respective platforms.
All the data we have on this product
Every VSF-related metafield surfaced verbatim. Nothing hidden. If you spot data that looks wrong, let us know.
- VSF score
- 84 / 100
- Tier
- Verified
- Category
- Supplements
- Subcategory
- vitamins micronutrients
- Last scored
- Third-party certifications
- None on record at time of scoring
- Vendor
- Take It or Leave It
- Tags
- Shopify Collective, Take It or Leave It
Every score is set from the published rubric, audit-logged, and rescored whenever new evidence emerges (published trials, updated labels, third-party testing releases). Every vendor is scored on the same criteria — no pay-to-play. See our editorial-independence disclosure for the full policy, including brands with an editorial relationship to this site.
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