Optimum Nutrition
THE BIOHACKING STANDARD
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Evergreen Apothecary Wild Yam Tallow is a topical cream combining wild yam root (Dioscorea villosa) and clary sage in a tallow (rendered beef fat) base, positioned for hormone balance and endogenous progesterone production. The core marketing claim — that wild yam encourages the body's own progesterone production — is a well-documented myth. Diosgenin, the sapogenin in wild yam, is a starting material used in INDUSTRIAL LABORATORY synthesis of progesterone (Marker degradation, 1940s pharmaceutical chemistry), but the human body cannot perform this multi-step chemical conversion. Diosgenin ingested or applied topically is NOT converted to progesterone in vivo (Komesaroff 2001 Climacteric randomized 23 postmenopausal women to topical wild yam cream vs placebo for 3 months and found NO change in progesterone, estradiol, FSH, LH, lipids, or symptom scores). The 'natural progesterone production' claim is unverified_medical_claim regardless of the product's other qualities. The topical tallow-plus-botanical formulation itself is not harmful, but the mechanism it claims to enact does not occur.
The Vyvata score's Evidence dimension measures the quality of published RCT support for a product's active ingredients at the label dose. Our source hierarchy: double-blind RCTs in MEDLINE-indexed journals > single-blind RCTs > open-label trials > observational studies > mechanism papers > N=1 case studies (anecdotes). Predatory journals and manufacturer-authored studies without independent replication are weighted down.
Product-specific evidence citations for this item are embedded in the analysis text on the "Analysis" tab. For the full framework and evidence hierarchy, see the methodology page.
FAQ data has not been generated for this product yet. See the site FAQ for general questions.
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