Optimum Nutrition
THE BIOHACKING STANDARD
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Saw palmetto (Serenoa repens) is one of the most-studied herbal supplements for benign prostatic hyperplasia (BPH), with a moderate evidence base. Early trials suggested benefit (Wilt 1998 meta-analysis) but larger and more rigorous trials showed less benefit (Barry 2011 CAMUS trial, JAMA, found saw palmetto 320-960mg/day equivalent to placebo for lower urinary tract symptoms). The current consensus is that saw palmetto has small effects on LUTS at 320mg/day of the standardized lipidosterolic extract, comparable to lifestyle modification but inferior to alpha-blockers or 5-alpha-reductase inhibitors for moderate-to-severe BPH. Drops format for saw palmetto is unusual — the evidence is primarily on the lipidosterolic extract (Permixon, Serenoa berry extract) delivered in capsules at 320mg/day. Vivalo does not disclose extraction ratio, standardization, or per-drop dose. Standard 50/100: real ingredient with moderate evidence for a narrow use case, held down by format uncertainty and no dose disclosure. Adding 'vitamin' to the name is misleading — no vitamins are disclosed.
The Vyvata score's Evidence dimension measures the quality of published RCT support for a product's active ingredients at the label dose. Our source hierarchy: double-blind RCTs in MEDLINE-indexed journals > single-blind RCTs > open-label trials > observational studies > mechanism papers > N=1 case studies (anecdotes). Predatory journals and manufacturer-authored studies without independent replication are weighted down.
Product-specific evidence citations for this item are embedded in the analysis text on the "Analysis" tab. For the full framework and evidence hierarchy, see the methodology page.
FAQ data has not been generated for this product yet. See the site FAQ for general questions.
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Every score is set from the published rubric, audit-logged, and rescored whenever new evidence emerges (published trials, updated labels, third-party testing releases). Every vendor is scored on the same criteria — no pay-to-play. See our editorial-independence disclosure for the full policy, including brands with an editorial relationship to this site.

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