Optimum Nutrition
THE BIOHACKING STANDARD
Welcome to our store
Couldn't load pickup availability
Everything Vyvata knows about this product — the score, the evidence, the FAQ, and where else to find shopper reviews. No hidden data. Every vendor is scored on the same published rubric — no brand can pay for placement. Read the rubric →
USP Labs Jack3d is one of the most safety-consequential brand names in the modern supplement industry. Original Jack3d (formulation era 2008-2013) contained DMAA (1,3-dimethylamylamine), a synthetic stimulant that the FDA banned from supplements in 2013 after DMAA was linked to multiple deaths including a 22-year-old US Army soldier and a 30-year-old marathon runner. The FDA's enforcement action against USP Labs also included criminal indictments of company executives, resulting in guilty pleas for conspiracy to defraud the FDA. Modern reformulated Jack3d does not contain DMAA, but the brand name itself carries safety-history weight — a reasonable buyer should evaluate this SKU with awareness of the brand's regulatory record. Even setting aside the historical context, Jack3d's current formulation follows the pre-workout category default: proprietary stimulant matrix, undisclosed individual doses. Autofail on proprietary_blend_hides_dose, with especially low safety-dimension score reflecting the DMAA history. Rejected tier — one of the lowest Rejected scores in this batch specifically because of the brand's regulatory and safety context.
The Vyvata score's Evidence dimension measures the quality of published RCT support for a product's active ingredients at the label dose. Our source hierarchy: double-blind RCTs in MEDLINE-indexed journals > single-blind RCTs > open-label trials > observational studies > mechanism papers > N=1 case studies (anecdotes). Predatory journals and manufacturer-authored studies without independent replication are weighted down.
Product-specific evidence citations for this item are embedded in the analysis text on the "Analysis" tab. For the full framework and evidence hierarchy, see the methodology page.
FAQ data has not been generated for this product yet. See the site FAQ for general questions.
The Vyvata score measures product integrity against a published rubric, not customer sentiment. Vyvata does not aggregate, republish, or license third-party reviews — the links below open search pages on their respective platforms.
Every VSF-related metafield surfaced verbatim. Nothing hidden. If you spot data that looks wrong, let us know.
Every score is set from the published rubric, audit-logged, and rescored whenever new evidence emerges (published trials, updated labels, third-party testing releases). Every vendor is scored on the same criteria — no pay-to-play. See our editorial-independence disclosure for the full policy, including brands with an editorial relationship to this site.

Optimum Nutrition
Onnit
WOW MD LLC
Prevagen
Find Your Protocol
A few quick questions about your goals and current concerns. We'll build a tailored protocol — a Basics list of essentials plus a comprehensive Biohackers list — across all Vyvata categories.
No signup required · Your protocol is private to you