Optimum Nutrition
THE BIOHACKING STANDARD
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Neurogan Health Urolithin A PRO Capsules deliver 1,000 mg of ultra-micronized Urolithin A per two-capsule serving, derived from ellagic acid (a pomegranate/walnut precursor). Urolithin A is a legitimate mitophagy-inducing molecule with a growing human evidence base — the AMAZ-02 trial (Andreux 2019) and the follow-on trial in older adults (Liu 2022) both showed improvements in mitochondrial biomarkers and muscle strength at 500-1,000 mg/day. Two caveats keep this in Standard tier rather than higher. (1) The gold-standard clinical evidence used Mitopure/Timeline's proprietary bioconverted urolithin A (matched for bioavailability), and independent-manufacturer versions have not been shown in head-to-head PK trials to reach equivalent plasma levels — micronization is a defensible attempt at bioavailability but not a demonstrated equivalence. (2) Per-lot certificates of analysis and Urolithin A purity/isomer-composition data are not clearly published on the SKU.
The Vyvata score's Evidence dimension measures the quality of published RCT support for a product's active ingredients at the label dose. Our source hierarchy: double-blind RCTs in MEDLINE-indexed journals > single-blind RCTs > open-label trials > observational studies > mechanism papers > N=1 case studies (anecdotes). Predatory journals and manufacturer-authored studies without independent replication are weighted down.
Product-specific evidence citations for this item are embedded in the analysis text on the "Analysis" tab. For the full framework and evidence hierarchy, see the methodology page.
FAQ data has not been generated for this product yet. See the site FAQ for general questions.
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