Total Longevity Upgrade

Six-dimension breakdown

Why this scored 52/100

Multi-ingredient '6-in-1' cellular energy, focus and longevity formula featuring liposomal NMN plus paraxanthine as headline actives, alongside additional supporting ingredients that are not fully quantified at the SKU-page level. The individual actives are legitimate: liposomal NMN has emerging pharmacokinetic support in humans (Yoshino, Trammell, and others) and paraxanthine is the primary human metabolite of caffeine with a favorable side-effect profile compared to caffeine itself in early studies (Yoo 2021, Xing 2024 small RCTs). What sinks the score: the 'longevity' framing is a strong claim that no over-the-counter supplement has cleared the FDA/EMA evidentiary bar for, the multi-ingredient combination is not disclosed with per-constituent milligrams for all six actives (proprietary-blend-adjacent structure), and there is no published RCT on this specific commercial formulation as sold. The '6-in-1 cellular energy + focus + longevity' framing packs three distinct claim territories into one SKU, none of which are individually validated for this exact combination and dose. Not autofailed outright because the individual actives are real and paraxanthine is a defensible focus/energy ingredient — but the aggregate longevity positioning and incomplete disclosure pattern place it in low-Rejected tier. Would move to Standard with full per-ingredient dose disclosure, narrower claim positioning (energy or focus, not longevity), and third-party COAs.

Evidence & sources

The Vyvata score's Evidence dimension measures the quality of published RCT support for a product's active ingredients at the label dose. Our source hierarchy: double-blind RCTs in MEDLINE-indexed journals > single-blind RCTs > open-label trials > observational studies > mechanism papers > N=1 case studies (anecdotes). Predatory journals and manufacturer-authored studies without independent replication are weighted down.

Product-specific evidence citations for this item are embedded in the analysis text on the "Analysis" tab. For the full framework and evidence hierarchy, see the methodology page.

How to read the Evidence dimension

• 80–100: Multiple double-blind RCTs in indexed journals directly testing this product OR the exact ingredients at the exact dose.
• 60–79: Single double-blind RCT + supporting ingredient literature at the studied dose.
• 40–59: Open-label trials + ingredient literature; no product-specific double-blind evidence.
• 20–39: Ingredient literature only; no product-specific trials or trials in predatory venues.
• 0–19: No credible evidence base or unverifiable claims.

FAQ data has not been generated for this product yet. See the site FAQ for general questions.

Customer reviews

All the data we have on this product

Every VSF-related metafield surfaced verbatim. Nothing hidden. If you spot data that looks wrong, let us know.

VSF score

52 / 100

Tier

Rejected

Category

Supplements

Subcategory

longevity cellular

Last scored

August 29, 2026

Third-party certifications

None on record at time of scoring

Vendor

Upgraded Formulas®

Product type

Supplements

Tags

Shopify Collective, Upgraded Formulas(R)

Every score is set from the published rubric, audit-logged, and rescored whenever new evidence emerges (published trials, updated labels, third-party testing releases). Every vendor is scored on the same criteria — no pay-to-play. See our editorial-independence disclosure for the full policy, including brands with an editorial relationship to this site.