Optimum Nutrition
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Second Annona-family product in this batch — this one specifically named 'Annona prickly fruit tincture' (Annona muricata, soursop/graviola) at 60ml. See Annona Aceratum Drops SKU for full analysis of the annonacin neurotoxin safety concern documented by Caparros-Lefebvre 1999 (Lancet), Champy 2005, Lannuzel 2008, and formal advisories from EFSA and French ANSES. A tincture (alcohol extract) is even more concentrated for acetogenin content than a fresh whole fruit. Autofailed under safety_concern. Rejected at 28.
The Vyvata score's Evidence dimension measures the quality of published RCT support for a product's active ingredients at the label dose. Our source hierarchy: double-blind RCTs in MEDLINE-indexed journals > single-blind RCTs > open-label trials > observational studies > mechanism papers > N=1 case studies (anecdotes). Predatory journals and manufacturer-authored studies without independent replication are weighted down.
Product-specific evidence citations for this item are embedded in the analysis text on the "Analysis" tab. For the full framework and evidence hierarchy, see the methodology page.
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