Super Aloe 450

Six-dimension breakdown

Why this scored 55/100

Super Aloe 450 is Ortho Molecular's concentrated Cape aloe (Aloe ferox) capsule at 450mg per dose — a stimulant laxative product with a distinctly different mechanism and safety profile than the aloe vera inner-leaf gel used in oral gut-healing formulations. Cape aloe contains anthraquinone glycosides (aloin, aloin A/B, aloeresins) that are metabolized by gut bacteria into anthrones, which stimulate intestinal peristalsis and increase water secretion into the colon lumen — producing a laxative effect within 6-12 hours. This is a real and effective mechanism for acute constipation relief and has documented pharmacological activity comparable to senna. Two significant safety flags apply: (1) chronic stimulant laxative use can cause laxative dependence (colon nerve down-regulation, cathartic colon syndrome) with long-term use over months; (2) FDA classified oral aloe anthraquinones as generally-not-recognized-as-safe in 2002 for chronic use in OTC laxative products (specifically because a rodent carcinogenicity study on aloin showed colon cancer signals — though the direct human relevance is contested and the dosing was much higher than typical human use). Ortho Molecular positions this as short-course use rather than daily maintenance, which is the appropriate framing. Standard tier: legitimate practitioner formulation with real short-course efficacy, tempered by chronic-use safety concerns.

Evidence & sources

The Vyvata score's Evidence dimension measures the quality of published RCT support for a product's active ingredients at the label dose. Our source hierarchy: double-blind RCTs in MEDLINE-indexed journals > single-blind RCTs > open-label trials > observational studies > mechanism papers > N=1 case studies (anecdotes). Predatory journals and manufacturer-authored studies without independent replication are weighted down.

Product-specific evidence citations for this item are embedded in the analysis text on the "Analysis" tab. For the full framework and evidence hierarchy, see the methodology page.

How to read the Evidence dimension

• 80–100: Multiple double-blind RCTs in indexed journals directly testing this product OR the exact ingredients at the exact dose.
• 60–79: Single double-blind RCT + supporting ingredient literature at the studied dose.
• 40–59: Open-label trials + ingredient literature; no product-specific double-blind evidence.
• 20–39: Ingredient literature only; no product-specific trials or trials in predatory venues.
• 0–19: No credible evidence base or unverifiable claims.

FAQ data has not been generated for this product yet. See the site FAQ for general questions.

Customer reviews

All the data we have on this product

Every VSF-related metafield surfaced verbatim. Nothing hidden. If you spot data that looks wrong, let us know.

VSF score

55 / 100

Tier

Standard

Category

Supplements

Subcategory

gut digestive

Last scored

August 30, 2026

Third-party certifications

None on record at time of scoring

Vendor

O Body + Wellness

Tags

O Body + Wellness, Shopify Collective

Every score is set from the published rubric, audit-logged, and rescored whenever new evidence emerges (published trials, updated labels, third-party testing releases). Every vendor is scored on the same criteria — no pay-to-play. See our editorial-independence disclosure for the full policy, including brands with an editorial relationship to this site.