Stopain Clinical Pain Relief

Six-dimension breakdown

Why this scored 60/100

Stopain Clinical is a professional-strength topical analgesic marketed by Troikaa Pharmaceuticals through practitioner and DTC channels. The formula discloses 10% menthol as the primary counterirritant active, with dimethylsulfone (MSM) and glucosamine included as ancillary joint-support ingredients. Topical menthol at 5-10% is a genuinely evidence-supported category — the Cochrane and academic-review literature (e.g., Derry 2017 for topical rubefacients; Higashi 2010 for menthol RCTs in DOMS and low-back pain) shows modest, real, short-term analgesic effect via TRPM8 receptor activation and a cooling counterirritant sensation. Effect sizes are small-to-moderate and short-duration (typically 1-4 hours per application), and topical menthol is not disease-modifying — it is symptomatic relief. The MSM and glucosamine additions are honest additions but the transdermal absorption evidence for oral-dose systemic-joint effects is thin; consider them as label-credibility inputs rather than proven joint-modifying actives. Manufactured by Troikaa (a legitimate Indian pharmaceutical company operating cGMP facilities), OTC-compliant labeling, gel-and-roll-on forms. Standard 60 sits at the middle of the topical-analgesic tier for us — real ingredient, honest labeling, modest evidence base. Would move to Verified 70+ with published head-to-head RCTs against Biofreeze / Icy Hot, and with clearer dose specification for the MSM and glucosamine content per application.

Evidence & sources

The Vyvata score's Evidence dimension measures the quality of published RCT support for a product's active ingredients at the label dose. Our source hierarchy: double-blind RCTs in MEDLINE-indexed journals > single-blind RCTs > open-label trials > observational studies > mechanism papers > N=1 case studies (anecdotes). Predatory journals and manufacturer-authored studies without independent replication are weighted down.

Product-specific evidence citations for this item are embedded in the analysis text on the "Analysis" tab. For the full framework and evidence hierarchy, see the methodology page.

How to read the Evidence dimension

• 80–100: Multiple double-blind RCTs in indexed journals directly testing this product OR the exact ingredients at the exact dose.
• 60–79: Single double-blind RCT + supporting ingredient literature at the studied dose.
• 40–59: Open-label trials + ingredient literature; no product-specific double-blind evidence.
• 20–39: Ingredient literature only; no product-specific trials or trials in predatory venues.
• 0–19: No credible evidence base or unverifiable claims.

FAQ data has not been generated for this product yet. See the site FAQ for general questions.

Customer reviews

All the data we have on this product

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VSF score

60 / 100

Tier

Standard

Category

Recovery regeneration

Subcategory

contrast therapy

Last scored

August 30, 2026

Third-party certifications

None on record at time of scoring

Vendor

Orthopedic Outfitters

Product type

First Aid

Tags

Orthopedic Outfitters, Shopify Collective

Every score is set from the published rubric, audit-logged, and rescored whenever new evidence emerges (published trials, updated labels, third-party testing releases). Every vendor is scored on the same criteria — no pay-to-play. See our editorial-independence disclosure for the full policy, including brands with an editorial relationship to this site.