Optimum Nutrition
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Nettle leaf (as opposed to root) is used for seasonal allergies (Mittman 1990 small RCT). Liquid extract offers dose flexibility and sub-lingual bioavailability. Alcohol/sugar-free is a positive for compliance. No marker standardization disclosed. Would move to Verified 70+ with a named freeze-dried leaf format (as in Mittman study) at studied dose.
The Vyvata score's Evidence dimension measures the quality of published RCT support for a product's active ingredients at the label dose. Our source hierarchy: double-blind RCTs in MEDLINE-indexed journals > single-blind RCTs > open-label trials > observational studies > mechanism papers > N=1 case studies (anecdotes). Predatory journals and manufacturer-authored studies without independent replication are weighted down.
Product-specific evidence citations for this item are embedded in the analysis text on the "Analysis" tab. For the full framework and evidence hierarchy, see the methodology page.
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Stinging Nettles Leaf Liquid Extract - Alcohol & Sugar Free, categorized under Immune health & antioxidants in the Supplements vertical. It is scored on the Vyvata Scoring Framework — an independent 6-dimension rubric applied uniformly to every product Vyvata lists.
58/100 overall — Standard tier (50–69 band). Per-dimension breakdown: Safety 66, Formulation 60, Transparency 60, Manufacturing 58, Evidence 55, Sustainability 52. Scored as of 2026-08-24.
Nettle leaf (as opposed to root) is used for seasonal allergies (Mittman 1990 small RCT). Liquid extract offers dose flexibility and sub-lingual bioavailability. Alcohol/sugar-free is a positive for compliance. No marker standardization disclosed. Would move to Verified 70+ with a named freeze-dried leaf format (as in Mittman study) at studied dose.
Strongest: Safety at 66/100 (adverse-event profile, interaction risk, and dose ceiling) and Formulation at 60/100 (dose adequacy, bioavailability form, and ingredient redundancy). Weakest: Evidence at 55/100 (quality of published RCT support for the active ingredients at the label dose) and Sustainability at 52/100 (sourcing practices, packaging, and corporate practice). All six dimensions feed the overall Vyvata score; a weakness on any one dimension pulls the overall down proportionally.
No third-party certifications (NSF, USP, ConsumerLab, or equivalent) were on record at the time of scoring. This affects the Manufacturing dimension score. The manufacturer may test internally or have obtained certification more recently — check the current product label for the most up-to-date information.
Would move to Verified 70+ with a named freeze-dried leaf format (as in Mittman study) at studied dose.
The top-ranked immune health & antioxidants product in the Vyvata catalog is currently PreserVision AREDS 2 Eye Vitamins, 210 Soft gels at 77/100. See the full ranked list of 590 scored products in this subcategory at https://vyvata.com/pages/best-immune-health-and-antioxidants-supplements-ranked.
The Vyvata Scoring Framework rates every listed product 0–100 across six dimensions: Evidence, Formulation, Manufacturing, Safety, Transparency, and Sustainability. Tier bands: Elite 85–100 (top-tier evidence + formulation + manufacturing), Verified 70–84 (strong on most dimensions), Standard 50–69 (solid but with weaknesses called out), Rejected 0–49 (specific failures documented). Rejected products remain listed with reasons. Full methodology at https://vyvata.com/pages/methodology.
The Vyvata score measures product integrity against a published rubric, not customer sentiment. For customer reviews and community discussion, search external platforms directly: Amazon (https://www.amazon.com/s?k=Stinging%20Nettles%20Leaf%20Liquid%20Extract%20-%20Alcohol%20%26%20Sugar%20Free),Google(https://www.google.com/search?q=Stinging%20Nettles%20Leaf%20Liquid%20Extract%20-%20Alcohol%20%26%20Sugar%20Free+reviews),Reddit(https://www.reddit.com/search/?q=Stinging%20Nettles%20Leaf%20Liquid%20Extract%20-%20Alcohol%20%26%20Sugar%20Free%20review),andTrustpilot(https://www.trustpilot.com/search?query=Stinging%20Nettles%20Leaf%20Liquid%20Extract%20-%20Alcohol%20%26%20Sugar%20Free).Vyvatadoesnotaggregate,republish,orlicensethosethird-partyreviews.
The Vyvata score measures product integrity against a published rubric, not customer sentiment. Vyvata does not aggregate, republish, or license third-party reviews — the links below open search pages on their respective platforms.
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Every score is set from the published rubric, audit-logged, and rescored whenever new evidence emerges (published trials, updated labels, third-party testing releases). Every vendor is scored on the same criteria — no pay-to-play. See our editorial-independence disclosure for the full policy, including brands with an editorial relationship to this site.

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