Optimum Nutrition
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[Rescored — SAFETY DOWNGRADE via evidence crawl] Previous score 67 → new 62. Evidence found: Miller ER 3rd, et al. Meta-analysis: high-dosage vitamin E supplementation may increase all-cause mortality. Ann Intern Med. 2005;142(1):37-46 (19 trials, n=135,967; dose-dependent risk above 400 IU/day). | Klein EA, et al. Vitamin E and the risk of prostate cancer: the Selenium and Vitamin E Cancer Prevention Trial (SELECT). JAMA. 2011;306(14):1549-56.. Rationale: 400 IU vitamin E as a daily supplement is at the threshold linked to increased all-cause mortality (Miller 2005 meta) and increased prostate cancer risk in men (SELECT trial). This is not a Solgar-specific problem - it applies to all 400 IU E supplements. Modest -5 downgrade (well within -25 cap) reflects the safety signal for chronic daily use at this dose.
The Vyvata score's Evidence dimension measures the quality of published RCT support for a product's active ingredients at the label dose. Our source hierarchy: double-blind RCTs in MEDLINE-indexed journals > single-blind RCTs > open-label trials > observational studies > mechanism papers > N=1 case studies (anecdotes). Predatory journals and manufacturer-authored studies without independent replication are weighted down.
Product-specific evidence citations for this item are embedded in the analysis text on the "Analysis" tab. For the full framework and evidence hierarchy, see the methodology page.
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Solgar Vitamin E 268 mg (400 IU) 100 Vegetarian Softgels is a product from Solgar, categorized under Vitamins & foundational micronutrients in the Supplements vertical. It is scored on the Vyvata Scoring Framework — an independent 6-dimension rubric applied uniformly to every product Vyvata lists.
67/100 overall — Standard tier (50–69 band). Per-dimension breakdown: Manufacturing 74, Transparency 70, Evidence 68, Formulation 65, Safety 65, Sustainability 58. Scored as of 2026-08-24.
Solgar is a well-regarded practitioner-tier brand, and the vegetarian softgel format is a real point of difference (most vitamin E softgels use bovine gelatin). The formulation concern is that 400 IU alpha-tocopherol-only vitamin E has evidence for isolated antioxidant support (Meydani 1997 for immune response in elderly) but modern evidence increasingly favors mixed tocopherols and tocotrienols to avoid displacing gamma-tocopherol from tissues (Jiang 2001). The Miller 2005 meta-analysis also raised mortality signals with high-dose alpha-tocopherol-only supplementation above 400 IU. Would move to Verified 70+ with a mixed tocopherol/tocotrienol complex rather than isolated alpha-tocopherol.
Strongest: Manufacturing at 74/100 (third-party testing, GMP compliance, and facility audit status) and Transparency at 70/100 (dose disclosure vs proprietary blends, and honesty of marketing claims). Weakest: Safety at 65/100 (adverse-event profile, interaction risk, and dose ceiling) and Sustainability at 58/100 (sourcing practices, packaging, and corporate practice). All six dimensions feed the overall Vyvata score; a weakness on any one dimension pulls the overall down proportionally.
No third-party certifications (NSF, USP, ConsumerLab, or equivalent) were on record at the time of scoring. This affects the Manufacturing dimension score. The manufacturer may test internally or have obtained certification more recently — check the current product label for the most up-to-date information.
Would move to Verified 70+ with a mixed tocopherol/tocotrienol complex rather than isolated alpha-tocopherol.
The top-ranked vitamins & foundational micronutrients product in the Vyvata catalog is currently Thorne Basic Nutrients 2/Day at 89/100. See the full ranked list of 635 scored products in this subcategory at https://vyvata.com/pages/best-vitamins-and-foundational-micronutrients-supplements-ranked.
The Vyvata Scoring Framework rates every listed product 0–100 across six dimensions: Evidence, Formulation, Manufacturing, Safety, Transparency, and Sustainability. Tier bands: Elite 85–100 (top-tier evidence + formulation + manufacturing), Verified 70–84 (strong on most dimensions), Standard 50–69 (solid but with weaknesses called out), Rejected 0–49 (specific failures documented). Rejected products remain listed with reasons. Full methodology at https://vyvata.com/pages/methodology.
The Vyvata score measures product integrity against a published rubric, not customer sentiment. For customer reviews and community discussion, search external platforms directly: Amazon (https://www.amazon.com/s?k=Solgar%20Solgar%20Vitamin%20E%20268%20mg%20(400%20IU)%20100%20Vegetarian%20Softgels),Google(https://www.google.com/search?q=Solgar%20Solgar%20Vitamin%20E%20268%20mg%20(400%20IU)%20100%20Vegetarian%20Softgels+reviews),Reddit(https://www.reddit.com/search/?q=Solgar%20Solgar%20Vitamin%20E%20268%20mg%20(400%20IU)%20100%20Vegetarian%20Softgels%20review),andTrustpilot(https://www.trustpilot.com/search?query=Solgar%20Solgar%20Vitamin%20E%20268%20mg%20(400%20IU)%20100%20Vegetarian%20Softgels).Vyvatadoesnotaggregate,republish,orlicensethosethird-partyreviews.
The Vyvata score measures product integrity against a published rubric, not customer sentiment. Vyvata does not aggregate, republish, or license third-party reviews — the links below open search pages on their respective platforms.
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Every score is set from the published rubric, audit-logged, and rescored whenever new evidence emerges (published trials, updated labels, third-party testing releases). Every vendor is scored on the same criteria — no pay-to-play. See our editorial-independence disclosure for the full policy, including brands with an editorial relationship to this site.

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