Optimum Nutrition
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[Rescored via evidence crawl] Previous score 72 → new 78. Evidence found: Stough C, et al. High-dose B-complex work stress trial. Hum Psychopharmacol. 2011;26(7):470-6. | Solgar Megasorb sustained-release delivery matrix (proprietary tablet coating).. Rationale: Megasorb '50' B-Complex uses Solgar's sustained-release tablet matrix at 50 mg per B vitamin - well above RDA and matched to the Stough 2011 protocol scale. Sustained-release format reduces the urine flush and gives more even blood levels. +6 uplift for the specific formulation edge plus B-complex evidence base.
The Vyvata score's Evidence dimension measures the quality of published RCT support for a product's active ingredients at the label dose. Our source hierarchy: double-blind RCTs in MEDLINE-indexed journals > single-blind RCTs > open-label trials > observational studies > mechanism papers > N=1 case studies (anecdotes). Predatory journals and manufacturer-authored studies without independent replication are weighted down.
Product-specific evidence citations for this item are embedded in the analysis text on the "Analysis" tab. For the full framework and evidence hierarchy, see the methodology page.
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Solgar Megasorb B-Complex "50" 100 Tablets is a product from Solgar, categorized under Vitamins & foundational micronutrients in the Supplements vertical. It is scored on the Vyvata Scoring Framework — an independent 6-dimension rubric applied uniformly to every product Vyvata lists.
72/100 overall — Verified tier (70–84 band). Per-dimension breakdown: Manufacturing 78, Formulation 74, Transparency 74, Evidence 72, Safety 72, Sustainability 62. Scored as of 2026-08-24.
Solgar Megasorb B-Complex '50' provides 50mg of each major B-vitamin — a high-potency stress-support B-complex. Solgar has 75+ years of manufacturing history, kosher/vegan certifications, and generally reliable QC. The '50' format is well above RDA and traditionally used for stress/energy protocols. Would move to Elite 85+ with methylfolate (5-MTHF) instead of folic acid and methylcobalamin B12.
Strongest: Manufacturing at 78/100 (third-party testing, GMP compliance, and facility audit status) and Formulation at 74/100 (dose adequacy, bioavailability form, and ingredient redundancy). Weakest: Safety at 72/100 (adverse-event profile, interaction risk, and dose ceiling) and Sustainability at 62/100 (sourcing practices, packaging, and corporate practice). All six dimensions feed the overall Vyvata score; a weakness on any one dimension pulls the overall down proportionally.
No third-party certifications (NSF, USP, ConsumerLab, or equivalent) were on record at the time of scoring. This affects the Manufacturing dimension score. The manufacturer may test internally or have obtained certification more recently — check the current product label for the most up-to-date information.
Would move to Elite 85+ with methylfolate (5-MTHF) instead of folic acid and methylcobalamin B12.
The top-ranked vitamins & foundational micronutrients product in the Vyvata catalog is currently Thorne Basic Nutrients 2/Day at 89/100. See the full ranked list of 635 scored products in this subcategory at https://vyvata.com/pages/best-vitamins-and-foundational-micronutrients-supplements-ranked.
The Vyvata Scoring Framework rates every listed product 0–100 across six dimensions: Evidence, Formulation, Manufacturing, Safety, Transparency, and Sustainability. Tier bands: Elite 85–100 (top-tier evidence + formulation + manufacturing), Verified 70–84 (strong on most dimensions), Standard 50–69 (solid but with weaknesses called out), Rejected 0–49 (specific failures documented). Rejected products remain listed with reasons. Full methodology at https://vyvata.com/pages/methodology.
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Every score is set from the published rubric, audit-logged, and rescored whenever new evidence emerges (published trials, updated labels, third-party testing releases). Every vendor is scored on the same criteria — no pay-to-play. See our editorial-independence disclosure for the full policy, including brands with an editorial relationship to this site.

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