Optimum Nutrition
THE BIOHACKING STANDARD
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Selenium is a genuinely essential trace mineral (RDA 55 mcg/day adults) required for the glutathione peroxidase and thioredoxin reductase antioxidant systems and for thyroid hormone deiodinase enzymes. Deficiency is uncommon in the US but real in parts of China, New Zealand, and Finland where soil selenium is low, and can present as Keshan cardiomyopathy or Kashin-Beck osteochondropathy. Modest evidence exists for selenium in Hashimoto's thyroiditis (autoimmune thyroid) reducing antibody levels at 200 mcg/day. The safety window is narrow — chronic intake above 400 mcg/day (tolerable upper intake) causes selenosis (hair and nail changes, GI symptoms, neuropathy). The description's antioxidant and immune framing is accurate; the product does not disclose the form (selenomethionine vs selenite) or per-serving mcg. Mid-Standard.
The Vyvata score's Evidence dimension measures the quality of published RCT support for a product's active ingredients at the label dose. Our source hierarchy: double-blind RCTs in MEDLINE-indexed journals > single-blind RCTs > open-label trials > observational studies > mechanism papers > N=1 case studies (anecdotes). Predatory journals and manufacturer-authored studies without independent replication are weighted down.
Product-specific evidence citations for this item are embedded in the analysis text on the "Analysis" tab. For the full framework and evidence hierarchy, see the methodology page.
FAQ data has not been generated for this product yet. See the site FAQ for general questions.
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