Optimum Nutrition
THE BIOHACKING STANDARD
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Resveratrol has an equivocal evidence base — early enthusiasm (Sinclair sirtuin-activation hypothesis, animal longevity models) has been tempered by disappointing human trials at typical doses (100-500mg/day). It has small effects on inflammatory markers (Poulsen 2013 meta-analysis) and some vascular endpoints, but no established evidence for sleep. The 'sleep supplement' claim for resveratrol is not supported by clinical trials — the compound has no known GABA-ergic, melatonergic, or otherwise sedative mechanism. The 'for men' qualifier is arbitrary — resveratrol has no sex-specific evidence. Combining a compound with weak evidence for one endpoint (resveratrol for antioxidant/vascular) with a claim it has no evidence for (sleep) is a marketing pattern designed to capture multiple search categories. Standard tier at 42, near the Rejected boundary: real ingredient with weak but real evidence for its actual use cases, but the 'sleep supplement' claim is unverified and the 'for men' qualifier is meaningless.
The Vyvata score's Evidence dimension measures the quality of published RCT support for a product's active ingredients at the label dose. Our source hierarchy: double-blind RCTs in MEDLINE-indexed journals > single-blind RCTs > open-label trials > observational studies > mechanism papers > N=1 case studies (anecdotes). Predatory journals and manufacturer-authored studies without independent replication are weighted down.
Product-specific evidence citations for this item are embedded in the analysis text on the "Analysis" tab. For the full framework and evidence hierarchy, see the methodology page.
FAQ data has not been generated for this product yet. See the site FAQ for general questions.
The Vyvata score measures product integrity against a published rubric, not customer sentiment. Vyvata does not aggregate, republish, or license third-party reviews — the links below open search pages on their respective platforms.
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Every score is set from the published rubric, audit-logged, and rescored whenever new evidence emerges (published trials, updated labels, third-party testing releases). Every vendor is scored on the same criteria — no pay-to-play. See our editorial-independence disclosure for the full policy, including brands with an editorial relationship to this site.

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