Optimum Nutrition
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[Rescored via evidence crawl] Previous score 78 → new 83. Evidence found: Van Ballegooijen AJ et al. The Synergistic Interplay between Vitamins D and K for Bone and Cardiovascular Health. Int J Endocrinol. 2017;2017:7454376. | Knapen MH et al. Three-year low-dose menaquinone-7 supplementation helps decrease bone loss in healthy postmenopausal women. Osteoporos Int. 2013;24(9):2499-2507 (MenaQ7 evidence).. Rationale: Combines 100 mcg (4000 IU) D3 with 100 mcg K2 as MenaQ7 (MK-7). This is the therapeutic-dose combination for bone and vascular calcium partitioning. Practitioner-grade hypoallergenic formulation. Elite tier.
The Vyvata score's Evidence dimension measures the quality of published RCT support for a product's active ingredients at the label dose. Our source hierarchy: double-blind RCTs in MEDLINE-indexed journals > single-blind RCTs > open-label trials > observational studies > mechanism papers > N=1 case studies (anecdotes). Predatory journals and manufacturer-authored studies without independent replication are weighted down.
Product-specific evidence citations for this item are embedded in the analysis text on the "Analysis" tab. For the full framework and evidence hierarchy, see the methodology page.
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Pure Encapsulations Vitamin D3 & K2 100/100 Mcg is a product from Pure Encapsulations, categorized under Vitamins & foundational micronutrients in the Supplements vertical. It is scored on the Vyvata Scoring Framework — an independent 6-dimension rubric applied uniformly to every product Vyvata lists.
78/100 overall — Verified tier (70–84 band). Per-dimension breakdown: Formulation 82, Evidence 78, Manufacturing 78, Safety 75, Transparency 75, Sustainability 55. Scored as of 2026-08-24.
Pure Encapsulations D3 (100 mcg = 4000 IU) + K2 (100 mcg MK-7) combo — practitioner-grade with reference-quality forms. MK-7 for K2 (longer half-life, better cardiovascular data than MK-4). Softgel format for D3 absorption. Pure Encapsulations manufacturing standards + hypoallergenic positioning. Highest-scoring D3+K2 combo product. Held below Elite by (1) sustainability profile thin; (2) no NSF Certified for Sport; (3) no third-party COA visible per-SKU. Would move to Elite 85+ with sustainability data + NSF cert.
Strongest: Formulation at 82/100 (dose adequacy, bioavailability form, and ingredient redundancy) and Evidence at 78/100 (quality of published RCT support for the active ingredients at the label dose). Weakest: Transparency at 75/100 (dose disclosure vs proprietary blends, and honesty of marketing claims) and Sustainability at 55/100 (sourcing practices, packaging, and corporate practice). All six dimensions feed the overall Vyvata score; a weakness on any one dimension pulls the overall down proportionally.
No third-party certifications (NSF, USP, ConsumerLab, or equivalent) were on record at the time of scoring. This affects the Manufacturing dimension score. The manufacturer may test internally or have obtained certification more recently — check the current product label for the most up-to-date information.
Would move to Elite 85+ with sustainability data + NSF cert.
The top-ranked vitamins & foundational micronutrients product in the Vyvata catalog is currently Thorne Basic Nutrients 2/Day at 89/100. See the full ranked list of 635 scored products in this subcategory at https://vyvata.com/pages/best-vitamins-and-foundational-micronutrients-supplements-ranked.
The Vyvata Scoring Framework rates every listed product 0–100 across six dimensions: Evidence, Formulation, Manufacturing, Safety, Transparency, and Sustainability. Tier bands: Elite 85–100 (top-tier evidence + formulation + manufacturing), Verified 70–84 (strong on most dimensions), Standard 50–69 (solid but with weaknesses called out), Rejected 0–49 (specific failures documented). Rejected products remain listed with reasons. Full methodology at https://vyvata.com/pages/methodology.
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The Vyvata score measures product integrity against a published rubric, not customer sentiment. Vyvata does not aggregate, republish, or license third-party reviews — the links below open search pages on their respective platforms.
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Every score is set from the published rubric, audit-logged, and rescored whenever new evidence emerges (published trials, updated labels, third-party testing releases). Every vendor is scored on the same criteria — no pay-to-play. See our editorial-independence disclosure for the full policy, including brands with an editorial relationship to this site.

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