Optimum Nutrition
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Ocean Methyl Balance is a Turkish-market methylation-support supplement combining Betaine (TMG), Choline, L-Serine, and B vitamins. Methylation support is a real evidence area — TMG at 1-6g/day lowers homocysteine (Olthof 2003), choline supports phosphatidylcholine synthesis, methylated B vitamins (methylfolate, methylcobalamin, P5P) support one-carbon metabolism especially in MTHFR C677T variants. The formulation logic is defensible; the concern is dose disclosure — TMG needs to be at 1000mg+ for clinical effect on homocysteine, and putting TMG + choline + L-serine + Bs into a single 30-capsule bottle at one-a-day dosing means each ingredient is likely sub-therapeutic (TMG at maybe 100-500mg, well below the 1000mg threshold). Turkish supplement regulation is lighter than US/EU. Rejected for the likely-sub-therapeutic dose pattern typical of stacked methylation blends and the lack of per-ingredient disclosure.
The Vyvata score's Evidence dimension measures the quality of published RCT support for a product's active ingredients at the label dose. Our source hierarchy: double-blind RCTs in MEDLINE-indexed journals > single-blind RCTs > open-label trials > observational studies > mechanism papers > N=1 case studies (anecdotes). Predatory journals and manufacturer-authored studies without independent replication are weighted down.
Product-specific evidence citations for this item are embedded in the analysis text on the "Analysis" tab. For the full framework and evidence hierarchy, see the methodology page.
FAQ data has not been generated for this product yet. See the site FAQ for general questions.
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