Ortho Spore IG 90ct

Six-dimension breakdown

Why this scored 64/100

Ortho Spore IG combines spore-based probiotic organisms (likely Bacillus coagulans, Bacillus subtilis, and Bacillus clausii — the three most-used commercial spore-forming probiotic Bacillus species) with serum-derived bovine immunoglobulins (SBI). The product is explicitly positioned for small intestinal bacterial overgrowth (SIBO). Two distinct actives, both with real published evidence: (1) Spore-forming Bacillus probiotics survive gastric acid because of their spore coats (unlike Lactobacillus and Bifidobacterium probiotics that need enteric coating), and B. clausii specifically has documented antibacterial and immunomodulatory activity in the small bowel that has been studied in SIBO contexts. (2) Serum-derived bovine immunoglobulins (SBI, branded as IgY Max or ImmunoLin depending on source) contain concentrated IgG antibodies that bind bacterial antigens and toxins in the gut lumen — Wilson 2013 and Weinstock 2014 showed SBI reduced HIV enteropathy and IBS-D symptoms respectively. This is a coherent SIBO-adjacent formulation. Standard tier reflecting real practitioner-formulated combination on a specific clinical use case, held below Verified by absent CFU counts and immunoglobulin dose disclosure at title level and by SIBO diagnosis and treatment properly requiring physician oversight beyond OTC supplementation.

Evidence & sources

The Vyvata score's Evidence dimension measures the quality of published RCT support for a product's active ingredients at the label dose. Our source hierarchy: double-blind RCTs in MEDLINE-indexed journals > single-blind RCTs > open-label trials > observational studies > mechanism papers > N=1 case studies (anecdotes). Predatory journals and manufacturer-authored studies without independent replication are weighted down.

Product-specific evidence citations for this item are embedded in the analysis text on the "Analysis" tab. For the full framework and evidence hierarchy, see the methodology page.

How to read the Evidence dimension

• 80–100: Multiple double-blind RCTs in indexed journals directly testing this product OR the exact ingredients at the exact dose.
• 60–79: Single double-blind RCT + supporting ingredient literature at the studied dose.
• 40–59: Open-label trials + ingredient literature; no product-specific double-blind evidence.
• 20–39: Ingredient literature only; no product-specific trials or trials in predatory venues.
• 0–19: No credible evidence base or unverifiable claims.

FAQ data has not been generated for this product yet. See the site FAQ for general questions.

Customer reviews

All the data we have on this product

Every VSF-related metafield surfaced verbatim. Nothing hidden. If you spot data that looks wrong, let us know.

VSF score

64 / 100

Tier

Standard

Category

Supplements

Subcategory

gut digestive

Last scored

August 30, 2026

Third-party certifications

None on record at time of scoring

Vendor

O Body + Wellness

Tags

O Body + Wellness, Shopify Collective

Every score is set from the published rubric, audit-logged, and rescored whenever new evidence emerges (published trials, updated labels, third-party testing releases). Every vendor is scored on the same criteria — no pay-to-play. See our editorial-independence disclosure for the full policy, including brands with an editorial relationship to this site.