Optimum Nutrition
THE BIOHACKING STANDARD
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A high-dose methylfolate (15 mg) plus B12 sublingual — clearly targeting the MTHFR / methylation-support audience rather than general use. Milligram disclosure earns transparency credit that most other SKUs in this brand line miss. The evidence context matters: 15 mg is a very high dose of L-5-MTHF, well above RDA (400 mcg DFE) and matching the doses used in prescription-strength L-methylfolate products such as Deplin, which are used adjunctively in refractory depression and in select MTHFR-related presentations. That is a legitimate clinical dose range, not casual daily use. Because the dose is prescription-magnitude and MTHFR is often self-diagnosed, safety scoring is trimmed — this SKU should not be used casually. Formulation and evidence for methylation support at high-dose methylfolate is genuine, and transparency is above average for this brand line.
The Vyvata score's Evidence dimension measures the quality of published RCT support for a product's active ingredients at the label dose. Our source hierarchy: double-blind RCTs in MEDLINE-indexed journals > single-blind RCTs > open-label trials > observational studies > mechanism papers > N=1 case studies (anecdotes). Predatory journals and manufacturer-authored studies without independent replication are weighted down.
Product-specific evidence citations for this item are embedded in the analysis text on the "Analysis" tab. For the full framework and evidence hierarchy, see the methodology page.
FAQ data has not been generated for this product yet. See the site FAQ for general questions.
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