Optimum Nutrition
THE BIOHACKING STANDARD
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Fruiting-body-only Hericium erinaceus extract in a 2 oz liquid tincture. The fruiting-body-only qualifier is genuinely important — much of the negative press around lion's mane 'not working' comes from myceliated grain products that are largely starch with trace mushroom, whereas fruiting-body extracts contain the hericenones and erinacines that drive the NGF-related neuroplasticity mechanism. Human evidence is small but consistent: Mori 2009 (Japanese adults 50-80, mild cognitive impairment, 3 g/day for 16 weeks) and Saitsu 2019 both show cognitive improvement vs placebo. Effect sizes are modest and only durable while dosing continues. The product does not disclose extract strength (e.g. beta-glucan percentage, hericenone content, extract ratio) or milligrams-per-serving, which caps the Verified potential. Fruiting-body sourcing and honest cognitive positioning earn mid-Standard credit — this is one of the better lion's mane products a small brand could ship, provided the ingredient claim is accurate.
The Vyvata score's Evidence dimension measures the quality of published RCT support for a product's active ingredients at the label dose. Our source hierarchy: double-blind RCTs in MEDLINE-indexed journals > single-blind RCTs > open-label trials > observational studies > mechanism papers > N=1 case studies (anecdotes). Predatory journals and manufacturer-authored studies without independent replication are weighted down.
Product-specific evidence citations for this item are embedded in the analysis text on the "Analysis" tab. For the full framework and evidence hierarchy, see the methodology page.
FAQ data has not been generated for this product yet. See the site FAQ for general questions.
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