Optimum Nutrition
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Nutrex Research HMB 1000 delivers 1000 mg calcium HMB (beta-hydroxy-beta-methylbutyrate) per serving in vegetable capsules, 60 servings per bottle. HMB is a metabolite of leucine with real ingredient-level evidence for reducing exercise-induced muscle protein breakdown, supporting recovery, and preserving lean mass during caloric deficit. Meta-analyses (Wilson 2013, Rowlands 2009) show consistent modest effects on lean mass preservation particularly in untrained subjects and older adults. The classic studied protocol is 3 g/day (typically split as 3x1g), so 1000 mg per serving matches one dose of the studied 3x1g protocol. Nutrex is a real US sports-nutrition brand with mass-retail distribution. Class-level evidence and disclosure profile are Standard-tier. Held from Verified by absence of Informed Sport / NSF Sport certification and by product-level marketing being reasonable rather than exceptional. Solid entry.
The Vyvata score's Evidence dimension measures the quality of published RCT support for a product's active ingredients at the label dose. Our source hierarchy: double-blind RCTs in MEDLINE-indexed journals > single-blind RCTs > open-label trials > observational studies > mechanism papers > N=1 case studies (anecdotes). Predatory journals and manufacturer-authored studies without independent replication are weighted down.
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