Optimum Nutrition
THE BIOHACKING STANDARD
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NutraBio ZMA delivers the original patented ZMA blend: zinc monomethionine aspartate, magnesium aspartate, and vitamin B6. The formulation was developed by Victor Conte's BALCO Labs in the 1990s with early studies showing testosterone-support and sleep-quality effects in athletes with zinc deficiency. The evidence base is more mixed than the marketing suggests: the original testosterone-boosting studies were in athletes with documented zinc/magnesium gaps (real deficiency correction can meaningfully affect hormones); subsequent RCTs in non-deficient trained athletes have shown minimal testosterone or performance effects. The sleep-quality effect is more consistent, driven primarily by the magnesium component. NutraBio's execution is transparent-label, third-party tested, and delivers the standard patented formulation cleanly. Standard-tier for a legitimate zinc/magnesium/B6 combination product; the testosterone-boost framing outpaces the trained-athlete RCT evidence.
The Vyvata score's Evidence dimension measures the quality of published RCT support for a product's active ingredients at the label dose. Our source hierarchy: double-blind RCTs in MEDLINE-indexed journals > single-blind RCTs > open-label trials > observational studies > mechanism papers > N=1 case studies (anecdotes). Predatory journals and manufacturer-authored studies without independent replication are weighted down.
Product-specific evidence citations for this item are embedded in the analysis text on the "Analysis" tab. For the full framework and evidence hierarchy, see the methodology page.
FAQ data has not been generated for this product yet. See the site FAQ for general questions.
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Every score is set from the published rubric, audit-logged, and rescored whenever new evidence emerges (published trials, updated labels, third-party testing releases). Every vendor is scored on the same criteria — no pay-to-play. See our editorial-independence disclosure for the full policy, including brands with an editorial relationship to this site.

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