Optimum Nutrition
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[Rescored via evidence crawl] Previous score 76 → new 85. Evidence found: Chandrasekhar K, Kapoor J, Anishetty S. A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults. Indian J Psychol Med. 2012;34(3):255-262. | Lopresti AL et al. An investigation into the stress-relieving and pharmacological actions of an ashwagandha (Withania somnifera) extract. Medicine (Baltimore). 2019;98(37):e17186. | Salve J et al. Adaptogenic and Anxiolytic Effects of Ashwagandha Root Extract in Healthy Adults. Cureus. 2019;11(12):e6466.. Rationale: KSM-66 is the most-studied branded ashwagandha extract with multiple positive RCTs at 600 mg/day for stress, cortisol, and anxiety (Chandrasekhar 2012, Lopresti 2019, Salve 2019). NutraBio's KSM-66 sourcing + full label transparency puts this at Elite tier.
The Vyvata score's Evidence dimension measures the quality of published RCT support for a product's active ingredients at the label dose. Our source hierarchy: double-blind RCTs in MEDLINE-indexed journals > single-blind RCTs > open-label trials > observational studies > mechanism papers > N=1 case studies (anecdotes). Predatory journals and manufacturer-authored studies without independent replication are weighted down.
Product-specific evidence citations for this item are embedded in the analysis text on the "Analysis" tab. For the full framework and evidence hierarchy, see the methodology page.
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NutraBio Ashwagandha KSM-66 - 60 Capsules is a product from Ultimate Sport Nutrition, categorized under Stress, mood & mental wellness in the Supplements vertical. It is scored on the Vyvata Scoring Framework — an independent 6-dimension rubric applied uniformly to every product Vyvata lists.
76/100 overall — Verified tier (70–84 band). Per-dimension breakdown: Evidence 82, Transparency 82, Formulation 80, Manufacturing 76, Safety 72, Sustainability 62. Scored as of 2026-08-24.
NutraBio is one of the most transparent-labeling US supplement brands (full-disclosure labels, in-house cGMP facility, published lot-level CoAs) and KSM-66 is the most clinically studied ashwagandha extract on the market — Chandrasekhar 2012 and Lopresti 2019 both used KSM-66 at 300-600 mg/day to demonstrate cortisol reduction and stress-scale improvements. Combining a serious manufacturer with a clinically-validated branded extract puts this comfortably in Verified. Below Elite because sustainability sourcing for withania isn't publicly documented and there is no NSF/Informed Sport certification on this SKU. Would move to Elite 85+ with third-party sport certification and a documented sustainability chain from farm to bottle.
Strongest: Evidence at 82/100 (quality of published RCT support for the active ingredients at the label dose) and Transparency at 82/100 (dose disclosure vs proprietary blends, and honesty of marketing claims). Weakest: Safety at 72/100 (adverse-event profile, interaction risk, and dose ceiling) and Sustainability at 62/100 (sourcing practices, packaging, and corporate practice). All six dimensions feed the overall Vyvata score; a weakness on any one dimension pulls the overall down proportionally.
No third-party certifications (NSF, USP, ConsumerLab, or equivalent) were on record at the time of scoring. This affects the Manufacturing dimension score. The manufacturer may test internally or have obtained certification more recently — check the current product label for the most up-to-date information.
Would move to Elite 85+ with third-party sport certification and a documented sustainability chain from farm to bottle.
The top-ranked stress, mood & mental wellness product in the Vyvata catalog is currently Momentous Sleep at 77/100. See the full ranked list of 247 scored products in this subcategory at https://vyvata.com/pages/best-stress-mood-and-mental-wellness-supplements-ranked.
The Vyvata Scoring Framework rates every listed product 0–100 across six dimensions: Evidence, Formulation, Manufacturing, Safety, Transparency, and Sustainability. Tier bands: Elite 85–100 (top-tier evidence + formulation + manufacturing), Verified 70–84 (strong on most dimensions), Standard 50–69 (solid but with weaknesses called out), Rejected 0–49 (specific failures documented). Rejected products remain listed with reasons. Full methodology at https://vyvata.com/pages/methodology.
The Vyvata score measures product integrity against a published rubric, not customer sentiment. For customer reviews and community discussion, search external platforms directly: Amazon (https://www.amazon.com/s?k=Ultimate%20Sport%20Nutrition%20NutraBio%20Ashwagandha%20KSM-66%20-%2060%20Capsules),Google(https://www.google.com/search?q=Ultimate%20Sport%20Nutrition%20NutraBio%20Ashwagandha%20KSM-66%20-%2060%20Capsules+reviews),Reddit(https://www.reddit.com/search/?q=Ultimate%20Sport%20Nutrition%20NutraBio%20Ashwagandha%20KSM-66%20-%2060%20Capsules%20review),andTrustpilot(https://www.trustpilot.com/search?query=Ultimate%20Sport%20Nutrition%20NutraBio%20Ashwagandha%20KSM-66%20-%2060%20Capsules).Vyvatadoesnotaggregate,republish,orlicensethosethird-partyreviews.
The Vyvata score measures product integrity against a published rubric, not customer sentiment. Vyvata does not aggregate, republish, or license third-party reviews — the links below open search pages on their respective platforms.
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Every score is set from the published rubric, audit-logged, and rescored whenever new evidence emerges (published trials, updated labels, third-party testing releases). Every vendor is scored on the same criteria — no pay-to-play. See our editorial-independence disclosure for the full policy, including brands with an editorial relationship to this site.

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