Optimum Nutrition
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Saffron extract 88.5 mg — very close to the studied dose (Lopresti 2014 review, Kell 2017 all use 30-88mg/day standardized saffron). Real evidence base for mild-moderate depression and mood support. Standardized saffron is one of the better-evidenced natural mood supplements. Held below Verified by (1) safranal/crocin standardization not disclosed at label level (Affron/Satiereal branded extracts specify these — generic doesn't); (2) NusaPure budget-brand manufacturing without third-party COA; (3) no branded-extract identification (Affron is the reference clinical-trial extract). Would move to Verified 70+ with named branded extract (Affron/Satiereal) + third-party assay.
The Vyvata score's Evidence dimension measures the quality of published RCT support for a product's active ingredients at the label dose. Our source hierarchy: double-blind RCTs in MEDLINE-indexed journals > single-blind RCTs > open-label trials > observational studies > mechanism papers > N=1 case studies (anecdotes). Predatory journals and manufacturer-authored studies without independent replication are weighted down.
Product-specific evidence citations for this item are embedded in the analysis text on the "Analysis" tab. For the full framework and evidence hierarchy, see the methodology page.
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NusaPure Saffron Extract 88.5mg 200 Veggie Caps (Vegetarian, Non-GMO, Vegan) is a product from NusaPure, categorized under Stress, mood & mental wellness in the Supplements vertical. It is scored on the Vyvata Scoring Framework — an independent 6-dimension rubric applied uniformly to every product Vyvata lists.
62/100 overall — Standard tier (50–69 band). Per-dimension breakdown: Safety 72, Evidence 68, Formulation 65, Transparency 62, Manufacturing 55, Sustainability 45. Scored as of 2026-08-24.
Saffron extract 88.5 mg — very close to the studied dose (Lopresti 2014 review, Kell 2017 all use 30-88mg/day standardized saffron). Real evidence base for mild-moderate depression and mood support. Standardized saffron is one of the better-evidenced natural mood supplements. Held below Verified by (1) safranal/crocin standardization not disclosed at label level (Affron/Satiereal branded extracts specify these — generic doesn't); (2) NusaPure budget-brand manufacturing without third-party COA; (3) no branded-extract identification (Affron is the reference clinical-trial extract). Would move to Verified 70+ with named branded extract (Affron/Satiereal) + third-party assay.
Strongest: Safety at 72/100 (adverse-event profile, interaction risk, and dose ceiling) and Evidence at 68/100 (quality of published RCT support for the active ingredients at the label dose). Weakest: Manufacturing at 55/100 (third-party testing, GMP compliance, and facility audit status) and Sustainability at 45/100 (sourcing practices, packaging, and corporate practice). All six dimensions feed the overall Vyvata score; a weakness on any one dimension pulls the overall down proportionally.
No third-party certifications (NSF, USP, ConsumerLab, or equivalent) were on record at the time of scoring. This affects the Manufacturing dimension score. The manufacturer may test internally or have obtained certification more recently — check the current product label for the most up-to-date information.
Would move to Verified 70+ with named branded extract (Affron/Satiereal) + third-party assay.
The top-ranked stress, mood & mental wellness product in the Vyvata catalog is currently Momentous Sleep at 77/100. See the full ranked list of 247 scored products in this subcategory at https://vyvata.com/pages/best-stress-mood-and-mental-wellness-supplements-ranked.
The Vyvata Scoring Framework rates every listed product 0–100 across six dimensions: Evidence, Formulation, Manufacturing, Safety, Transparency, and Sustainability. Tier bands: Elite 85–100 (top-tier evidence + formulation + manufacturing), Verified 70–84 (strong on most dimensions), Standard 50–69 (solid but with weaknesses called out), Rejected 0–49 (specific failures documented). Rejected products remain listed with reasons. Full methodology at https://vyvata.com/pages/methodology.
The Vyvata score measures product integrity against a published rubric, not customer sentiment. For customer reviews and community discussion, search external platforms directly: Amazon (https://www.amazon.com/s?k=NusaPure%20NusaPure%20Saffron%20Extract%2088.5mg%20200%20Veggie%20Caps%20(Vegetarian%2C%20Non-GMO%2C%20Vegan)),Google(https://www.google.com/search?q=NusaPure%20NusaPure%20Saffron%20Extract%2088.5mg%20200%20Veggie%20Caps%20(Vegetarian%2C%20Non-GMO%2C%20Vegan)+reviews),Reddit(https://www.reddit.com/search/?q=NusaPure%20NusaPure%20Saffron%20Extract%2088.5mg%20200%20Veggie%20Caps%20(Vegetarian%2C%20Non-GMO%2C%20Vegan)%20review),andTrustpilot(https://www.trustpilot.com/search?query=NusaPure%20NusaPure%20Saffron%20Extract%2088.5mg%20200%20Veggie%20Caps%20(Vegetarian%2C%20Non-GMO%2C%20Vegan)).Vyvatadoesnotaggregate,republish,orlicensethosethird-partyreviews.
The Vyvata score measures product integrity against a published rubric, not customer sentiment. Vyvata does not aggregate, republish, or license third-party reviews — the links below open search pages on their respective platforms.
Every VSF-related metafield surfaced verbatim. Nothing hidden. If you spot data that looks wrong, let us know.
Every score is set from the published rubric, audit-logged, and rescored whenever new evidence emerges (published trials, updated labels, third-party testing releases). Every vendor is scored on the same criteria — no pay-to-play. See our editorial-independence disclosure for the full policy, including brands with an editorial relationship to this site.

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