Optimum Nutrition
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NusaPure African Mango 10:1 Extract at 500 mg per capsule uses a non-branded generic Irvingia gabonensis extract. The published weight-loss evidence for African mango comes almost exclusively from studies using the IGOB131 branded extract at 150 mg twice daily (Ngondi 2005, Ngondi 2009, Oben 2008) — a specific standardized extract from a specific Cameroonian source. Concerns exist about the reproducibility of the Ngondi results: subsequent independent trials (Judd 2019, Onakpoya 2013 Cochrane-style review) have found the evidence base underpowered and single-source-dependent, and the American Society for Nutrition Journal of Nutrition raised concerns about IGOB131 study methodology. Generic 10:1 African mango extract (implying 5 g raw seed equivalent per 500 mg dose) does not automatically inherit whatever benefit IGOB131 may have and cannot be matched to any dose-response curve. Additionally, weight-loss supplements in this category are consistently overpromised and underdelivered. Rejected under sub_therapeutic_dose.
The Vyvata score's Evidence dimension measures the quality of published RCT support for a product's active ingredients at the label dose. Our source hierarchy: double-blind RCTs in MEDLINE-indexed journals > single-blind RCTs > open-label trials > observational studies > mechanism papers > N=1 case studies (anecdotes). Predatory journals and manufacturer-authored studies without independent replication are weighted down.
Product-specific evidence citations for this item are embedded in the analysis text on the "Analysis" tab. For the full framework and evidence hierarchy, see the methodology page.
FAQ data has not been generated for this product yet. See the site FAQ for general questions.
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