Optimum Nutrition
THE BIOHACKING STANDARD
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NOW Foods is a well-established US supplement brand founded in 1968 with an in-house quality control program (they operate multiple ISO-certified testing labs). L-Lysine 500 mg is a single-ingredient tablet at a disclosed dose, 100-tablet supply for cost-effective long-term use. Same evidence base as the Solgar L-Lysine 1000 mg SKU scored earlier — moderate RCT evidence for HSV-1 outbreak reduction at daily doses of 1000-3000 mg (Griffith 1978, DiGiovanna 1984). 500 mg per tablet gives users granular dose control (2-6 tablets/day for typical HSV protocols). NOW's brand-level manufacturing quality is credible; NOW is one of the more commonly-cited brands in independent testing publications with generally-good labeling accuracy. Standard-tier entry — held from Verified by absence of visible USP certification on this specific SKU (NOW has USP-Verified products but not all SKUs). Solid single-ingredient basic.
The Vyvata score's Evidence dimension measures the quality of published RCT support for a product's active ingredients at the label dose. Our source hierarchy: double-blind RCTs in MEDLINE-indexed journals > single-blind RCTs > open-label trials > observational studies > mechanism papers > N=1 case studies (anecdotes). Predatory journals and manufacturer-authored studies without independent replication are weighted down.
Product-specific evidence citations for this item are embedded in the analysis text on the "Analysis" tab. For the full framework and evidence hierarchy, see the methodology page.
FAQ data has not been generated for this product yet. See the site FAQ for general questions.
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Every score is set from the published rubric, audit-logged, and rescored whenever new evidence emerges (published trials, updated labels, third-party testing releases). Every vendor is scored on the same criteria — no pay-to-play. See our editorial-independence disclosure for the full policy, including brands with an editorial relationship to this site.

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