Optimum Nutrition
THE BIOHACKING STANDARD
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Nature's Truth is a mid-tier US mass-retail supplement brand (Piping Rock-affiliated, NY). DHEA (dehydroepiandrosterone) at 25mg is a prohormone that converts to both testosterone and estrogens in the body. DHEA is a schedule III controlled substance in Canada and banned by WADA/NCAA/most sports federations. The evidence for DHEA supplementation is genuinely mixed: some benefit in adrenal insufficiency (Arlt 1999) and postmenopausal women with low libido and low DHEA-S (Genazzani 2011), but no consistent benefit for general 'anti-aging' or 'vitality' in healthy adults with normal DHEA. Safety concerns include acne, hair loss, mood changes, elevated liver enzymes, and — importantly — theoretical increase in hormone-sensitive cancer risk (breast, prostate, ovarian). The listing is skeletal and does not discuss any of this. Rejected for the combination of (a) hormone-active ingredient with genuine safety flags, (b) minimal safety framing in the listing, and (c) evidence-to-marketing gap.
The Vyvata score's Evidence dimension measures the quality of published RCT support for a product's active ingredients at the label dose. Our source hierarchy: double-blind RCTs in MEDLINE-indexed journals > single-blind RCTs > open-label trials > observational studies > mechanism papers > N=1 case studies (anecdotes). Predatory journals and manufacturer-authored studies without independent replication are weighted down.
Product-specific evidence citations for this item are embedded in the analysis text on the "Analysis" tab. For the full framework and evidence hierarchy, see the methodology page.
FAQ data has not been generated for this product yet. See the site FAQ for general questions.
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