Nature Made Co Q10, Extra Strength, 400 Mg, Softgels

Six-dimension breakdown

Why this scored 71/100

Nature Made is a mainstream US supplement brand (Pharmavite, owned by Otsuka Pharmaceutical) with USP verification on many of its SKUs — USP verification is one of the strongest independent third-party quality signals in the supplement industry, covering identity, potency, purity from contaminants including heavy metals, and manufacturing quality. Nature Made CoQ10 has held USP verification historically (check the specific bottle for the USP-verified mark). Extra Strength 400 mg per softgel is a moderate-to-high dose — well above the 100-200 mg typical daily target and appropriate for statin-associated muscle symptoms, mild heart-failure adjunct use, or blood pressure protocols. Softgel format provides the necessary lipid-based delivery for adequate CoQ10 absorption. Ubiquinone form (the traditional cheaper form; ubiquinol is better absorbed particularly in older adults). Manufacturing scores highest of the CoQ10 SKUs in this batch because of Pharmavite's regulatory-grade manufacturing infrastructure and the USP third-party verification. Modest marks off for the moderately-high dose being more than average consumers need and for standard-sustainability profile.

Evidence & sources

The Vyvata score's Evidence dimension measures the quality of published RCT support for a product's active ingredients at the label dose. Our source hierarchy: double-blind RCTs in MEDLINE-indexed journals > single-blind RCTs > open-label trials > observational studies > mechanism papers > N=1 case studies (anecdotes). Predatory journals and manufacturer-authored studies without independent replication are weighted down.

Product-specific evidence citations for this item are embedded in the analysis text on the "Analysis" tab. For the full framework and evidence hierarchy, see the methodology page.

How to read the Evidence dimension

• 80–100: Multiple double-blind RCTs in indexed journals directly testing this product OR the exact ingredients at the exact dose.
• 60–79: Single double-blind RCT + supporting ingredient literature at the studied dose.
• 40–59: Open-label trials + ingredient literature; no product-specific double-blind evidence.
• 20–39: Ingredient literature only; no product-specific trials or trials in predatory venues.
• 0–19: No credible evidence base or unverifiable claims.

FAQ data has not been generated for this product yet. See the site FAQ for general questions.

Customer reviews

All the data we have on this product

Every VSF-related metafield surfaced verbatim. Nothing hidden. If you spot data that looks wrong, let us know.

VSF score

71 / 100

Tier

Standard

Category

Supplements

Subcategory

cardiovascular heart

Last scored

August 24, 2026

Third-party certifications

None on record at time of scoring

Vendor

Pasteur Pharmacy

Product type

Vitamins & Supplements

Tags

Pasteur Pharmacy, Shopify Collective

Every score is set from the published rubric, audit-logged, and rescored whenever new evidence emerges (published trials, updated labels, third-party testing releases). Every vendor is scored on the same criteria — no pay-to-play. See our editorial-independence disclosure for the full policy, including brands with an editorial relationship to this site.