Optimum Nutrition
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This is a combination collagen product fortified per the description with vitamin D, calcium, and L-leucine, targeting joint, muscle, and bone support. The individual actives are all well-characterized: hydrolyzed collagen peptides at 10-15g/day have moderate evidence for reducing joint pain in athletes (Clark 2008, Zdzieblik 2017), calcium and vitamin D are the pillar bone-density interventions in the medical literature, and L-leucine is the primary trigger for muscle protein synthesis via mTORC1 signaling (needs ~2.5-3g per meal to hit the leucine threshold). The formula is coherent on paper. Weakness: the product does not disclose collagen source (bovine hide, marine, chicken sternal type II), per-serving milligrams of each active, molecular weight of the collagen peptides (which affects absorption), or standardization of the vitamin D and calcium forms (K2 co-formulation for calcium partitioning is absent based on the ingredient list). At 20 servings the tub is a fairly small supply (three-week course), which is typical for a joint-support cycle but suggests dosing frequency guidance would help. Standard tier: legitimate combination product covering three real areas, but not a premium formulation with disclosed collagen type/molecular weight, K2 pairing, or third-party assay.
The Vyvata score's Evidence dimension measures the quality of published RCT support for a product's active ingredients at the label dose. Our source hierarchy: double-blind RCTs in MEDLINE-indexed journals > single-blind RCTs > open-label trials > observational studies > mechanism papers > N=1 case studies (anecdotes). Predatory journals and manufacturer-authored studies without independent replication are weighted down.
Product-specific evidence citations for this item are embedded in the analysis text on the "Analysis" tab. For the full framework and evidence hierarchy, see the methodology page.
FAQ data has not been generated for this product yet. See the site FAQ for general questions.
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