Optimum Nutrition
THE BIOHACKING STANDARD
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Evergreen Apothecary's 'Milk Thistle Seed Capsules' title strongly implies raw ground seed rather than a standardized silymarin extract — an important distinction. Raw milk thistle seed contains only 1.5-3% silymarin by weight, meaning even a 500-1000 mg capsule of raw seed delivers only ~15-30 mg silymarin, well below the 150-300 mg therapeutic range established in NAFLD trials (Zhong 2019). Small artisan herbalist brands often sell raw seed as a whole-food-philosophy product, but at consumer doses this is functionally sub-therapeutic for the hepatoprotective effect the herb is known for. Autofailed on sub_therapeutic_dose grounds — the product delivers a nominal 'milk thistle' but almost certainly not a clinically effective silymarin dose.
The Vyvata score's Evidence dimension measures the quality of published RCT support for a product's active ingredients at the label dose. Our source hierarchy: double-blind RCTs in MEDLINE-indexed journals > single-blind RCTs > open-label trials > observational studies > mechanism papers > N=1 case studies (anecdotes). Predatory journals and manufacturer-authored studies without independent replication are weighted down.
Product-specific evidence citations for this item are embedded in the analysis text on the "Analysis" tab. For the full framework and evidence hierarchy, see the methodology page.
FAQ data has not been generated for this product yet. See the site FAQ for general questions.
The Vyvata score measures product integrity against a published rubric, not customer sentiment. Vyvata does not aggregate, republish, or license third-party reviews — the links below open search pages on their respective platforms.
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Every score is set from the published rubric, audit-logged, and rescored whenever new evidence emerges (published trials, updated labels, third-party testing releases). Every vendor is scored on the same criteria — no pay-to-play. See our editorial-independence disclosure for the full policy, including brands with an editorial relationship to this site.

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