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Methylation Screening Test
Methylation Screening Test
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Regular price
$125.00 USD
Regular price
Sale price
$125.00 USD
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The full picture
Everything Vyvata knows about this product — the score, the evidence, the FAQ, and where else to find shopper reviews. No hidden data. Every vendor is scored on the same published rubric — no brand can pay for placement. Read the rubric →
58/100
Standard
Six-dimension breakdown
Transparency
55
Why this scored 58/100
A methylation-pathway genetic panel (typically MTHFR C677T/A1298C, COMT, MTR, MTRR, CBS variants) using standard PCR that any CLIA-certified molecular lab can run reliably. Analytical accuracy of the genotyping itself is high — the underlying assay technology is well-validated for these single-nucleotide polymorphisms. The clinical utility problem is severe: the American College of Medical Genetics (ACMG) explicitly recommends against routine MTHFR testing, and mainstream genetics does not support methylation-panel results driving supplement or health decisions. Popular in functional-medicine circles but not evidence-based for the interpretations most vendors provide. Processing lab is not clearly disclosed. Would need explicit ACMG-aligned interpretation guidance and lab disclosure to move higher.
Last scored: Full rubric →
Evidence & sources
The Vyvata score's Evidence dimension measures the quality of published RCT support for a product's active ingredients at the label dose. Our source hierarchy: double-blind RCTs in MEDLINE-indexed journals > single-blind RCTs > open-label trials > observational studies > mechanism papers > N=1 case studies (anecdotes). Predatory journals and manufacturer-authored studies without independent replication are weighted down.
Product-specific evidence citations for this item are embedded in the analysis text on the "Analysis" tab. For the full framework and evidence hierarchy, see the methodology page.
How to read the Evidence dimension
- 80–100: Multiple double-blind RCTs in indexed journals directly testing this product OR the exact ingredients at the exact dose.
- 60–79: Single double-blind RCT + supporting ingredient literature at the studied dose.
- 40–59: Open-label trials + ingredient literature; no product-specific double-blind evidence.
- 20–39: Ingredient literature only; no product-specific trials or trials in predatory venues.
- 0–19: No credible evidence base or unverifiable claims.
FAQ data has not been generated for this product yet. See the site FAQ for general questions.
Customer reviews
Reviews on other platforms
The Vyvata score measures product integrity against a published rubric, not customer sentiment. Vyvata does not aggregate, republish, or license third-party reviews — the links below open search pages on their respective platforms.
All the data we have on this product
Every VSF-related metafield surfaced verbatim. Nothing hidden. If you spot data that looks wrong, let us know.
- VSF score
- 58 / 100
- Tier
- Standard
- Category
- Diagnostics testing
- Subcategory
- genetic dna
- Last scored
- Third-party certifications
- None on record at time of scoring
- Vendor
- hellohealth
- Tags
- hellohealth, Shopify Collective
Every score is set from the published rubric, audit-logged, and rescored whenever new evidence emerges (published trials, updated labels, third-party testing releases). Every vendor is scored on the same criteria — no pay-to-play. See our editorial-independence disclosure for the full policy, including brands with an editorial relationship to this site.
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