Optimum Nutrition
THE BIOHACKING STANDARD
Welcome to our store
Couldn't load pickup availability
Everything Vyvata knows about this product — the score, the evidence, the FAQ, and where else to find shopper reviews. No hidden data. Every vendor is scored on the same published rubric — no brand can pay for placement. Read the rubric →
Manganese is an essential trace mineral (adequate intake 1.8-2.3 mg/day) used as a cofactor for manganese superoxide dismutase (MnSOD), arginase, glutamine synthetase, and pyruvate carboxylase. Dietary intake is nearly always sufficient in the general population (whole grains, nuts, legumes, tea). Deficiency in humans is essentially unheard of outside experimental settings. The safety concern with supplemental manganese is real: chronic overexposure is associated with manganism, a neurologic syndrome resembling parkinsonism, historically documented in welders and mining populations. Water sources with elevated manganese have been epidemiologically associated with cognitive deficits in children. The tolerable upper intake in adults is 11 mg/day — supplementation risks approaching this. Rejected on the mismatch between no real deficiency population and documented neurotoxicity risk with supplemental use.
The Vyvata score's Evidence dimension measures the quality of published RCT support for a product's active ingredients at the label dose. Our source hierarchy: double-blind RCTs in MEDLINE-indexed journals > single-blind RCTs > open-label trials > observational studies > mechanism papers > N=1 case studies (anecdotes). Predatory journals and manufacturer-authored studies without independent replication are weighted down.
Product-specific evidence citations for this item are embedded in the analysis text on the "Analysis" tab. For the full framework and evidence hierarchy, see the methodology page.
FAQ data has not been generated for this product yet. See the site FAQ for general questions.
The Vyvata score measures product integrity against a published rubric, not customer sentiment. Vyvata does not aggregate, republish, or license third-party reviews — the links below open search pages on their respective platforms.
Every VSF-related metafield surfaced verbatim. Nothing hidden. If you spot data that looks wrong, let us know.
Every score is set from the published rubric, audit-logged, and rescored whenever new evidence emerges (published trials, updated labels, third-party testing releases). Every vendor is scored on the same criteria — no pay-to-play. See our editorial-independence disclosure for the full policy, including brands with an editorial relationship to this site.

Optimum Nutrition
Onnit
WOW MD LLC
Prevagen
Find Your Protocol
A few quick questions about your goals and current concerns. We'll build a tailored protocol — a Basics list of essentials plus a comprehensive Biohackers list — across all Vyvata categories.
No signup required · Your protocol is private to you