Magnesium Threonate 60ct

Six-dimension breakdown

Why this scored 71/100

Magnesium L-threonate — the branded ingredient Magtein, developed by Guosong Liu's group at MIT (Slutsky 2010) and licensed through AIDP — is the only magnesium form with published evidence for meaningfully crossing the blood-brain barrier and elevating cerebrospinal fluid magnesium concentration. The Slutsky 2010 rodent study and the Liu 2016 human trial (n=44, 12 weeks at 1.5-2g Magtein/day) showed improvements in cognitive function, particularly executive function and working memory, in older adults. Magnesium is a required cofactor for over 300 enzymatic reactions and a modulator of NMDA glutamate receptor activity in the brain — mechanistically it is a plausible cognitive-support intervention. Ortho Molecular's Mag Threonate delivers 2g of concentrated magnesium L-threonate per two capsules (which is the dose used in the human trial), and Ortho Molecular's practitioner-brand manufacturing quality is a real quality signal. This is one of the better single-active picks in this batch. Verified tier reflecting best-in-class magnesium form for cognitive support, delivered at the clinically-tested dose from a quality brand. Held out of Elite tier by the single-trial nature of the human evidence base and by the price premium (Magtein costs 3-5x per gram vs. other magnesium forms).

Evidence & sources

The Vyvata score's Evidence dimension measures the quality of published RCT support for a product's active ingredients at the label dose. Our source hierarchy: double-blind RCTs in MEDLINE-indexed journals > single-blind RCTs > open-label trials > observational studies > mechanism papers > N=1 case studies (anecdotes). Predatory journals and manufacturer-authored studies without independent replication are weighted down.

Product-specific evidence citations for this item are embedded in the analysis text on the "Analysis" tab. For the full framework and evidence hierarchy, see the methodology page.

How to read the Evidence dimension

• 80–100: Multiple double-blind RCTs in indexed journals directly testing this product OR the exact ingredients at the exact dose.
• 60–79: Single double-blind RCT + supporting ingredient literature at the studied dose.
• 40–59: Open-label trials + ingredient literature; no product-specific double-blind evidence.
• 20–39: Ingredient literature only; no product-specific trials or trials in predatory venues.
• 0–19: No credible evidence base or unverifiable claims.

FAQ data has not been generated for this product yet. See the site FAQ for general questions.

Customer reviews

All the data we have on this product

Every VSF-related metafield surfaced verbatim. Nothing hidden. If you spot data that looks wrong, let us know.

VSF score

71 / 100

Tier

Verified

Category

Supplements

Subcategory

cognitive nootropics

Last scored

August 30, 2026

Third-party certifications

None on record at time of scoring

Vendor

O Body + Wellness

Tags

O Body + Wellness, Shopify Collective

Every score is set from the published rubric, audit-logged, and rescored whenever new evidence emerges (published trials, updated labels, third-party testing releases). Every vendor is scored on the same criteria — no pay-to-play. See our editorial-independence disclosure for the full policy, including brands with an editorial relationship to this site.