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L-Glutathione - Featuring Setria Glutathione
L-Glutathione - Featuring Setria Glutathione
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Regular price
$19.49 USD
Regular price
Sale price
$19.49 USD
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The full picture
Everything Vyvata knows about this product — the score, the evidence, the FAQ, and where else to find shopper reviews. No hidden data. Every vendor is scored on the same published rubric — no brand can pay for placement. Read the rubric →
68/100
Standard
Six-dimension breakdown
Evidence
68
Formulation
65
Manufacturing
74
Safety
72
Transparency
70
Sustainability
58
Why this scored 68/100
Setria (Kyowa Hakko) is the branded, fermentation-derived reduced L-glutathione backed by Richie 2015 — the one oral glutathione RCT showing sustained rises in body glutathione stores at 250-1000 mg/day over six months. That study is why Setria is a real formulation upgrade over generic glutathione (which is largely broken down in the gut). Held at top of Standard rather than Verified because oral GSH still underperforms liposomal delivery and NAC precursor approaches for many indications, and Swanson's Setria capsules typically top out around 100-200 mg — below the Richie protocol. Would move to Verified 70+ at 500-1000 mg/day dose.
Last scored: Full rubric →
Evidence & sources
The Vyvata score's Evidence dimension measures the quality of published RCT support for a product's active ingredients at the label dose. Our source hierarchy: double-blind RCTs in MEDLINE-indexed journals > single-blind RCTs > open-label trials > observational studies > mechanism papers > N=1 case studies (anecdotes). Predatory journals and manufacturer-authored studies without independent replication are weighted down.
Product-specific evidence citations for this item are embedded in the analysis text on the "Analysis" tab. For the full framework and evidence hierarchy, see the methodology page.
How to read the Evidence dimension
- 80–100: Multiple double-blind RCTs in indexed journals directly testing this product OR the exact ingredients at the exact dose.
- 60–79: Single double-blind RCT + supporting ingredient literature at the studied dose.
- 40–59: Open-label trials + ingredient literature; no product-specific double-blind evidence.
- 20–39: Ingredient literature only; no product-specific trials or trials in predatory venues.
- 0–19: No credible evidence base or unverifiable claims.
Frequently asked questions
Auto-generated from Vyvata's scoring data for this product. For general questions about the store (shipping, returns, wholesale), see the site FAQ.
What is L-Glutathione - Featuring Setria Glutathione?
L-Glutathione - Featuring Setria Glutathione, categorized under Immune health & antioxidants in the Supplements vertical. It is scored on the Vyvata Scoring Framework — an independent 6-dimension rubric applied uniformly to every product Vyvata lists.
How does L-Glutathione - Featuring Setria Glutathione score on the Vyvata rubric?
68/100 overall — Standard tier (50–69 band). Per-dimension breakdown: Manufacturing 74, Safety 72, Transparency 70, Evidence 68, Formulation 65, Sustainability 58. Scored as of 2026-08-24.
Why did L-Glutathione - Featuring Setria Glutathione score in the Standard tier?
Setria (Kyowa Hakko) is the branded, fermentation-derived reduced L-glutathione backed by Richie 2015 — the one oral glutathione RCT showing sustained rises in body glutathione stores at 250-1000 mg/day over six months. That study is why Setria is a real formulation upgrade over generic glutathione (which is largely broken down in the gut). Held at top of Standard rather than Verified because oral GSH still underperforms liposomal delivery and NAC precursor approaches for many indications, and Swanson's Setria capsules typically top out around 100-200 mg — below the Richie protocol. Would move to Verified 70+ at 500-1000 mg/day dose.
What are the strongest and weakest aspects of this product?
Strongest: Manufacturing at 74/100 (third-party testing, GMP compliance, and facility audit status) and Safety at 72/100 (adverse-event profile, interaction risk, and dose ceiling). Weakest: Formulation at 65/100 (dose adequacy, bioavailability form, and ingredient redundancy) and Sustainability at 58/100 (sourcing practices, packaging, and corporate practice). All six dimensions feed the overall Vyvata score; a weakness on any one dimension pulls the overall down proportionally.
Is L-Glutathione - Featuring Setria Glutathione third-party tested?
No third-party certifications (NSF, USP, ConsumerLab, or equivalent) were on record at the time of scoring. This affects the Manufacturing dimension score. The manufacturer may test internally or have obtained certification more recently — check the current product label for the most up-to-date information.
What would move L-Glutathione - Featuring Setria Glutathione to a higher tier?
Would move to Verified 70+ at 500-1000 mg/day dose.
Are there higher-scoring alternatives to L-Glutathione - Featuring Setria Glutathione?
The top-ranked immune health & antioxidants product in the Vyvata catalog is currently PreserVision AREDS 2 Eye Vitamins, 210 Soft gels at 77/100. See the full ranked list of 590 scored products in this subcategory at https://vyvata.com/pages/best-immune-health-and-antioxidants-supplements-ranked.
What does the Vyvata score mean?
The Vyvata Scoring Framework rates every listed product 0–100 across six dimensions: Evidence, Formulation, Manufacturing, Safety, Transparency, and Sustainability. Tier bands: Elite 85–100 (top-tier evidence + formulation + manufacturing), Verified 70–84 (strong on most dimensions), Standard 50–69 (solid but with weaknesses called out), Rejected 0–49 (specific failures documented). Rejected products remain listed with reasons. Full methodology at https://vyvata.com/pages/methodology.
Where can I read customer reviews for L-Glutathione - Featuring Setria Glutathione?
The Vyvata score measures product integrity against a published rubric, not customer sentiment. For customer reviews and community discussion, search external platforms directly: Amazon (https://www.amazon.com/s?k=L-Glutathione%20-%20Featuring%20Setria%20Glutathione),Google(https://www.google.com/search?q=L-Glutathione%20-%20Featuring%20Setria%20Glutathione+reviews),Reddit(https://www.reddit.com/search/?q=L-Glutathione%20-%20Featuring%20Setria%20Glutathione%20review),andTrustpilot(https://www.trustpilot.com/search?query=L-Glutathione%20-%20Featuring%20Setria%20Glutathione).Vyvatadoesnotaggregate,republish,orlicensethosethird-partyreviews.
Customer reviews
Reviews on other platforms
The Vyvata score measures product integrity against a published rubric, not customer sentiment. Vyvata does not aggregate, republish, or license third-party reviews — the links below open search pages on their respective platforms.
All the data we have on this product
Every VSF-related metafield surfaced verbatim. Nothing hidden. If you spot data that looks wrong, let us know.
- VSF score
- 68 / 100
- Tier
- Standard
- Category
- Supplements
- Subcategory
- immune antioxidants
- Last scored
- Third-party certifications
- None on record at time of scoring
- Vendor
- Swanson Vitamins
- Tags
- Shopify Collective, Swanson Vitamins
Every score is set from the published rubric, audit-logged, and rescored whenever new evidence emerges (published trials, updated labels, third-party testing releases). Every vendor is scored on the same criteria — no pay-to-play. See our editorial-independence disclosure for the full policy, including brands with an editorial relationship to this site.
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