Optimum Nutrition
THE BIOHACKING STANDARD
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The D3+K2 combination is one of the best-evidenced micronutrient pairings — vitamin D3 for calcium absorption and immune modulation (LeBoff 2022 VITAL bone analysis, Martineau 2017 D3 respiratory infection meta), and K2 (MK-7 form) to direct calcium into bone rather than arterial soft-tissue (Knapen 2013 3-year osteocalcin trial). 5,000 IU D3 is a therapeutic dose appropriate for many deficient adults but excessive for repletion once serum 25(OH)D is optimized — labeling should ideally recommend baseline testing. K2 form (MK-4 vs MK-7) and mcg dose are the transparency question — MK-7 at 90-180 mcg is the well-studied form. Would move to Verified 75+ with MK-7 specification, mcg disclosure, and serum-monitoring guidance for the 5,000 IU D3 dose.
The Vyvata score's Evidence dimension measures the quality of published RCT support for a product's active ingredients at the label dose. Our source hierarchy: double-blind RCTs in MEDLINE-indexed journals > single-blind RCTs > open-label trials > observational studies > mechanism papers > N=1 case studies (anecdotes). Predatory journals and manufacturer-authored studies without independent replication are weighted down.
Product-specific evidence citations for this item are embedded in the analysis text on the "Analysis" tab. For the full framework and evidence hierarchy, see the methodology page.
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