Optimum Nutrition
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Glutathione Skin Supplement
Glutathione Skin Supplement
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Regular price
$40.70 USD
Regular price
Sale price
$40.70 USD
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The full picture
Everything Vyvata knows about this product — the score, the evidence, the FAQ, and where else to find shopper reviews. No hidden data. Every vendor is scored on the same published rubric — no brand can pay for placement. Read the rubric →
48/100
Rejected
Six-dimension breakdown
Evidence
12
Formulation
10
Manufacturing
10
Safety
7
Transparency
6
Sustainability
4
Why this scored 48/100
Glutathione is the body's most abundant intracellular antioxidant tripeptide (glutamate-cysteine-glycine). Oral glutathione has a contested bioavailability profile — early pharmacokinetic studies showed poor absorption because gut peptidases hydrolyze the molecule, but newer trials with liposomal and sublingual forms show meaningful plasma-level increases (Sinha et al. 2018, Eur J Clin Nutr found 500mg/day oral for 6 months increased blood GSH by 30% and skin lightening in Filipino subjects). For the skin-lightening claim specifically, there is a moderate evidence base in Asian populations at 250-1000mg/day but efficacy in fair-skinned populations is weaker and no FDA-approved 'skin lightening' oral supplement exists. This SKU discloses only 'glutathione' as raw material with no dose, form (reduced GSH vs liposomal vs S-acetyl-glutathione), or per-lot COA. Held at 48/100 in the low-Standard band: the ingredient has partial evidence for the claimed use, but the form/dose opacity keeps it near the Rejected threshold. Bumped above the autofail line only because glutathione has a real evidence file, unlike homeopathic 'skin drops.'
Last scored: Full rubric →
Evidence & sources
The Vyvata score's Evidence dimension measures the quality of published RCT support for a product's active ingredients at the label dose. Our source hierarchy: double-blind RCTs in MEDLINE-indexed journals > single-blind RCTs > open-label trials > observational studies > mechanism papers > N=1 case studies (anecdotes). Predatory journals and manufacturer-authored studies without independent replication are weighted down.
Product-specific evidence citations for this item are embedded in the analysis text on the "Analysis" tab. For the full framework and evidence hierarchy, see the methodology page.
How to read the Evidence dimension
- 80–100: Multiple double-blind RCTs in indexed journals directly testing this product OR the exact ingredients at the exact dose.
- 60–79: Single double-blind RCT + supporting ingredient literature at the studied dose.
- 40–59: Open-label trials + ingredient literature; no product-specific double-blind evidence.
- 20–39: Ingredient literature only; no product-specific trials or trials in predatory venues.
- 0–19: No credible evidence base or unverifiable claims.
FAQ data has not been generated for this product yet. See the site FAQ for general questions.
Customer reviews
Reviews on other platforms
The Vyvata score measures product integrity against a published rubric, not customer sentiment. Vyvata does not aggregate, republish, or license third-party reviews — the links below open search pages on their respective platforms.
All the data we have on this product
Every VSF-related metafield surfaced verbatim. Nothing hidden. If you spot data that looks wrong, let us know.
- VSF score
- 48 / 100
- Tier
- Rejected
- Category
- Supplements
- Subcategory
- skin hair beauty
- Last scored
- Third-party certifications
- None on record at time of scoring
- Vendor
- Vivalo
- Product type
- 0
- Tags
- Shopify Collective, Vivalo
Every score is set from the published rubric, audit-logged, and rescored whenever new evidence emerges (published trials, updated labels, third-party testing releases). Every vendor is scored on the same criteria — no pay-to-play. See our editorial-independence disclosure for the full policy, including brands with an editorial relationship to this site.
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