Optimum Nutrition
THE BIOHACKING STANDARD
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Epimedium (horny goat weed, Epimedium sagittatum) is standardized on its icariin content — the flavonoid identified as the primary PDE-5-inhibitor-like active. Meaningful in-vitro and animal doses translate to human doses of 600-900mg of standardized 20% icariin extract; typical DTC capsules deliver 250-500mg of raw powder with 2-5% icariin, which is 5-30x below the modeled active dose. The product title does not disclose milligrams per capsule or icariin standardization percentage. Additionally, horny goat weed products share the male-enhancement category's PDE-5-adulteration risk (icariin's structural similarity to sildenafil makes it a candidate for spike adulteration to boost perceived efficacy). Auto-failed under proprietary_blend_hides_dose for the missing standardization.
The Vyvata score's Evidence dimension measures the quality of published RCT support for a product's active ingredients at the label dose. Our source hierarchy: double-blind RCTs in MEDLINE-indexed journals > single-blind RCTs > open-label trials > observational studies > mechanism papers > N=1 case studies (anecdotes). Predatory journals and manufacturer-authored studies without independent replication are weighted down.
Product-specific evidence citations for this item are embedded in the analysis text on the "Analysis" tab. For the full framework and evidence hierarchy, see the methodology page.
FAQ data has not been generated for this product yet. See the site FAQ for general questions.
The Vyvata score measures product integrity against a published rubric, not customer sentiment. Vyvata does not aggregate, republish, or license third-party reviews — the links below open search pages on their respective platforms.
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Every score is set from the published rubric, audit-logged, and rescored whenever new evidence emerges (published trials, updated labels, third-party testing releases). Every vendor is scored on the same criteria — no pay-to-play. See our editorial-independence disclosure for the full policy, including brands with an editorial relationship to this site.

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