Optimum Nutrition
THE BIOHACKING STANDARD
Welcome to our store
Couldn't load pickup availability
Everything Vyvata knows about this product — the score, the evidence, the FAQ, and where else to find shopper reviews. No hidden data. Every vendor is scored on the same published rubric — no brand can pay for placement. Read the rubric →
1000 IU synthetic or natural vitamin E far exceeds the 15 mg (22 IU) RDA and the Miller 2005 meta-analysis specifically flagged mortality signal at high-dose alpha-only vitamin E. Isolated alpha-tocopherol at this dose also displaces gamma-tocopherol from tissues. Legit product for a legit brand but the dose is out of step with current evidence. Would move higher only with a mixed tocopherol/tocotrienol format at more physiologic dosing.
The Vyvata score's Evidence dimension measures the quality of published RCT support for a product's active ingredients at the label dose. Our source hierarchy: double-blind RCTs in MEDLINE-indexed journals > single-blind RCTs > open-label trials > observational studies > mechanism papers > N=1 case studies (anecdotes). Predatory journals and manufacturer-authored studies without independent replication are weighted down.
Product-specific evidence citations for this item are embedded in the analysis text on the "Analysis" tab. For the full framework and evidence hierarchy, see the methodology page.
Auto-generated from Vyvata's scoring data for this product. For general questions about the store (shipping, returns, wholesale), see the site FAQ.
E-1000, categorized under Vitamins & foundational micronutrients in the Supplements vertical. It is scored on the Vyvata Scoring Framework — an independent 6-dimension rubric applied uniformly to every product Vyvata lists.
55/100 overall — Standard tier (50–69 band). Per-dimension breakdown: Transparency 62, Manufacturing 58, Formulation 55, Safety 50, Sustainability 50, Evidence 48. Scored as of 2026-08-24.
1000 IU synthetic or natural vitamin E far exceeds the 15 mg (22 IU) RDA and the Miller 2005 meta-analysis specifically flagged mortality signal at high-dose alpha-only vitamin E. Isolated alpha-tocopherol at this dose also displaces gamma-tocopherol from tissues. Legit product for a legit brand but the dose is out of step with current evidence. Would move higher only with a mixed tocopherol/tocotrienol format at more physiologic dosing.
Strongest: Transparency at 62/100 (dose disclosure vs proprietary blends, and honesty of marketing claims) and Manufacturing at 58/100 (third-party testing, GMP compliance, and facility audit status). Weakest: Sustainability at 50/100 (sourcing practices, packaging, and corporate practice) and Evidence at 48/100 (quality of published RCT support for the active ingredients at the label dose). All six dimensions feed the overall Vyvata score; a weakness on any one dimension pulls the overall down proportionally.
No third-party certifications (NSF, USP, ConsumerLab, or equivalent) were on record at the time of scoring. This affects the Manufacturing dimension score. The manufacturer may test internally or have obtained certification more recently — check the current product label for the most up-to-date information.
The top-ranked vitamins & foundational micronutrients product in the Vyvata catalog is currently Thorne Basic Nutrients 2/Day at 89/100. See the full ranked list of 635 scored products in this subcategory at https://vyvata.com/pages/best-vitamins-and-foundational-micronutrients-supplements-ranked.
The Vyvata Scoring Framework rates every listed product 0–100 across six dimensions: Evidence, Formulation, Manufacturing, Safety, Transparency, and Sustainability. Tier bands: Elite 85–100 (top-tier evidence + formulation + manufacturing), Verified 70–84 (strong on most dimensions), Standard 50–69 (solid but with weaknesses called out), Rejected 0–49 (specific failures documented). Rejected products remain listed with reasons. Full methodology at https://vyvata.com/pages/methodology.
The Vyvata score measures product integrity against a published rubric, not customer sentiment. For customer reviews and community discussion, search external platforms directly: Amazon (https://www.amazon.com/s?k=E-1000),Google(https://www.google.com/search?q=E-1000+reviews),Reddit(https://www.reddit.com/search/?q=E-1000%20review),andTrustpilot(https://www.trustpilot.com/search?query=E-1000).Vyvatadoesnotaggregate,republish,orlicensethosethird-partyreviews.
The Vyvata score measures product integrity against a published rubric, not customer sentiment. Vyvata does not aggregate, republish, or license third-party reviews — the links below open search pages on their respective platforms.
Every VSF-related metafield surfaced verbatim. Nothing hidden. If you spot data that looks wrong, let us know.
Every score is set from the published rubric, audit-logged, and rescored whenever new evidence emerges (published trials, updated labels, third-party testing releases). Every vendor is scored on the same criteria — no pay-to-play. See our editorial-independence disclosure for the full policy, including brands with an editorial relationship to this site.

Optimum Nutrition
Onnit
WOW MD LLC
Prevagen
Find Your Protocol
A few quick questions about your goals and current concerns. We'll build a tailored protocol — a Basics list of essentials plus a comprehensive Biohackers list — across all Vyvata categories.
No signup required · Your protocol is private to you