Optimum Nutrition
THE BIOHACKING STANDARD
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DietWorks Cider Trim combines apple cider vinegar with green tea, garcinia cambogia, green coffee extract, cayenne, and ginger in a multi-ingredient capsule marketed for weight support. Three failures compound to push this below 45. (1) 'Cider Trim' branding and the multi-ingredient thermogenic blend positioning invokes weight-loss benefit; the underlying evidence for these ingredients (garcinia hydroxycitric acid, green coffee chlorogenic acid, cayenne capsaicin) is either negative or weakly positive at doses higher than a shared capsule can practically deliver — a 2020 Cochrane review on garcinia (Onakpoya) concluded 'clinically relevant weight-loss effect cannot be confirmed.' (2) Per-ingredient milligrams for the six actives are not disclosed in the description reviewed, tripping the proprietary-blend concern. (3) Green tea extract at unspecified concentration has documented hepatotoxicity signals at high doses (FDA warned in 2022 on EGCG-heavy supplements). Rejected on evidence + disclosure gaps + safety flag on green tea extract.
The Vyvata score's Evidence dimension measures the quality of published RCT support for a product's active ingredients at the label dose. Our source hierarchy: double-blind RCTs in MEDLINE-indexed journals > single-blind RCTs > open-label trials > observational studies > mechanism papers > N=1 case studies (anecdotes). Predatory journals and manufacturer-authored studies without independent replication are weighted down.
Product-specific evidence citations for this item are embedded in the analysis text on the "Analysis" tab. For the full framework and evidence hierarchy, see the methodology page.
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