Optimum Nutrition
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Evergreen Apothecary Cortisol Cleanup Tincture is positioned as adaptogenic stress support for symptoms of dysregulated cortisol (wired-tired feeling, sleep-onset difficulty, anxiety, brain fog, overwhelm). The naming 'Cortisol Cleanup' is more marketing than physiology — the body cannot 'clean up' cortisol; healthy HPA axis function regulates cortisol production and clearance. However, adaptogenic herb tinctures for stress support are a defensible category with real (if modest) evidence: ashwagandha standardized extracts at 300-600 mg/day reduce cortisol in stressed adults (Chandrasekhar 2012, Lopresti 2019); rhodiola at 200-400 mg/day for stress-related fatigue (Panossian 2010); holy basil (tulsi) at 500-1000 mg/day for stress markers (Cohen 2014); L-theanine at 200 mg for acute stress response. Specific ingredient list and per-herb dose disclosure not visible in the description snippet. Standard tier for defensible adaptogenic direction; held there by the metaphorical 'cleanup' naming and dose disclosure gap.
The Vyvata score's Evidence dimension measures the quality of published RCT support for a product's active ingredients at the label dose. Our source hierarchy: double-blind RCTs in MEDLINE-indexed journals > single-blind RCTs > open-label trials > observational studies > mechanism papers > N=1 case studies (anecdotes). Predatory journals and manufacturer-authored studies without independent replication are weighted down.
Product-specific evidence citations for this item are embedded in the analysis text on the "Analysis" tab. For the full framework and evidence hierarchy, see the methodology page.
FAQ data has not been generated for this product yet. See the site FAQ for general questions.
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Every score is set from the published rubric, audit-logged, and rescored whenever new evidence emerges (published trials, updated labels, third-party testing releases). Every vendor is scored on the same criteria — no pay-to-play. See our editorial-independence disclosure for the full policy, including brands with an editorial relationship to this site.

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