CollaGEN Stick Packs

Six-dimension breakdown

Why this scored 63/100

CollaGEN is Ortho Molecular's connective-tissue support formula combining collagen peptides with amino acid cofactors and micronutrients (typically L-glutamine, L-proline, L-lysine, N-acetyl-glucosamine, and vitamin C — cofactors for endogenous collagen synthesis). Ortho Molecular's practitioner-channel formulation quality is strong, and the mechanistic pitch is coherent: hydrolyzed collagen provides the specific proline/hydroxyproline/glycine substrate, vitamin C is required for prolyl and lysyl hydroxylase activity in collagen post-translational modification, and glucosamine adds a cartilage-matrix component. The stick pack format supports flexible dosing and travel. Clinical evidence for the individual actives is real: 10-15g/day collagen peptides has moderate joint-pain and skin-elasticity evidence, vitamin C is uncontroversial cofactor territory, glucosamine has modest but real joint-symptom evidence in mild-to-moderate osteoarthritis. Standard tier reflects legitimate practitioner-grade formulation with real evidence-supported actives, tempered by absent per-active milligram disclosure in retail-visible metadata and multi-active blend structure that may not hit clinical-dose thresholds for each component.

Evidence & sources

The Vyvata score's Evidence dimension measures the quality of published RCT support for a product's active ingredients at the label dose. Our source hierarchy: double-blind RCTs in MEDLINE-indexed journals > single-blind RCTs > open-label trials > observational studies > mechanism papers > N=1 case studies (anecdotes). Predatory journals and manufacturer-authored studies without independent replication are weighted down.

Product-specific evidence citations for this item are embedded in the analysis text on the "Analysis" tab. For the full framework and evidence hierarchy, see the methodology page.

How to read the Evidence dimension

• 80–100: Multiple double-blind RCTs in indexed journals directly testing this product OR the exact ingredients at the exact dose.
• 60–79: Single double-blind RCT + supporting ingredient literature at the studied dose.
• 40–59: Open-label trials + ingredient literature; no product-specific double-blind evidence.
• 20–39: Ingredient literature only; no product-specific trials or trials in predatory venues.
• 0–19: No credible evidence base or unverifiable claims.

FAQ data has not been generated for this product yet. See the site FAQ for general questions.

Customer reviews

All the data we have on this product

Every VSF-related metafield surfaced verbatim. Nothing hidden. If you spot data that looks wrong, let us know.

VSF score

63 / 100

Tier

Standard

Category

Supplements

Subcategory

joint bone connective

Last scored

August 30, 2026

Third-party certifications

None on record at time of scoring

Vendor

O Body + Wellness

Tags

O Body + Wellness, Shopify Collective

Every score is set from the published rubric, audit-logged, and rescored whenever new evidence emerges (published trials, updated labels, third-party testing releases). Every vendor is scored on the same criteria — no pay-to-play. See our editorial-independence disclosure for the full policy, including brands with an editorial relationship to this site.