Optimum Nutrition
THE BIOHACKING STANDARD
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L-citrulline and L-arginine are both nitric-oxide (NO) precursors used in sports supplementation for vasodilation ('pump'), endurance, and mild blood-pressure effects. L-citrulline has better oral bioavailability than L-arginine (arginine is degraded by intestinal arginase; citrulline is not, and is then converted to arginine in the kidneys, producing higher and more sustained plasma arginine than direct arginine supplementation — Schwedhelm 2008). Effective doses: L-citrulline 6-8g/day (as citrulline malate 8-10g), or L-arginine 3-6g/day. Combined citrulline+arginine is redundant biologically (citrulline becomes arginine), but marketing-common. This SKU discloses no per-capsule mg for either ingredient. Standard 58/100: real ingredients with real evidence for their claimed uses, held down by undisclosed doses.
The Vyvata score's Evidence dimension measures the quality of published RCT support for a product's active ingredients at the label dose. Our source hierarchy: double-blind RCTs in MEDLINE-indexed journals > single-blind RCTs > open-label trials > observational studies > mechanism papers > N=1 case studies (anecdotes). Predatory journals and manufacturer-authored studies without independent replication are weighted down.
Product-specific evidence citations for this item are embedded in the analysis text on the "Analysis" tab. For the full framework and evidence hierarchy, see the methodology page.
FAQ data has not been generated for this product yet. See the site FAQ for general questions.
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