Optimum Nutrition
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Buffered C is Ortho Molecular's vitamin C capsule using calcium, magnesium, and potassium ascorbate salts rather than plain ascorbic acid — the buffered form is chosen for gastric tolerance in users who experience acid-mediated stomach upset from high-dose plain ascorbic acid. Vitamin C itself is well-characterized (see earlier MRI Vitamin C entry). The buffered format delivers the same absorbed ascorbate ion as plain ascorbic acid, with better GI tolerance at higher doses. Ortho Molecular's positioning as a practitioner-channel brand implies strong manufacturing QC — the calcium/magnesium/potassium mineral ratios in a well-formulated buffered C matter (excess calcium can crowd out magnesium absorption over time, and imbalanced ratios can create their own issues), so brand-level QC on this specific format matters more than for plain ascorbic acid. Standard tier at the upper end reflecting a legitimate practitioner-brand formulation of a well-characterized nutrient in a genuinely superior format for a subset of users (those with plain ascorbic acid intolerance).
The Vyvata score's Evidence dimension measures the quality of published RCT support for a product's active ingredients at the label dose. Our source hierarchy: double-blind RCTs in MEDLINE-indexed journals > single-blind RCTs > open-label trials > observational studies > mechanism papers > N=1 case studies (anecdotes). Predatory journals and manufacturer-authored studies without independent replication are weighted down.
Product-specific evidence citations for this item are embedded in the analysis text on the "Analysis" tab. For the full framework and evidence hierarchy, see the methodology page.
FAQ data has not been generated for this product yet. See the site FAQ for general questions.
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Every score is set from the published rubric, audit-logged, and rescored whenever new evidence emerges (published trials, updated labels, third-party testing releases). Every vendor is scored on the same criteria — no pay-to-play. See our editorial-independence disclosure for the full policy, including brands with an editorial relationship to this site.

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