Optimum Nutrition
THE BIOHACKING STANDARD
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Nu Skin Bone Formula is positioned as a nutrient bundle supporting three bone-health mechanisms — bone formation, calcium absorption, and inhibition of bone loss — with 'novel sources of calcium and vitamin K' called out in the copy. Products in this segment typically combine calcium (usually citrate or hydroxyapatite, sometimes carbonate), magnesium, vitamin D3, vitamin K (K1 or K2 as MK-4/MK-7), and often boron, silica, and manganese. Evidence: calcium + D3 for postmenopausal bone density has Grade A evidence (WHI, MoS trials), though the effect size for fracture reduction in the general community-dwelling population is modest (Bolland 2015 meta-analysis). Vitamin K2 (MK-7) at 180mcg/day has Grade B evidence for postmenopausal bone density improvement (Knapen 2013). Magnesium and boron have Grade C support. Whether Nu Skin's Bone Formula delivers the studied doses (1000-1200mg calcium, 1000-2000 IU D3, 180mcg K2) depends on the label. The 'novel sources' claim suggests hydroxyapatite calcium or MK-4 vitamin K — plausible if disclosed. Standard tier as a reasonable bone-nutrient bundle in a competent brand; MLM channel and dose-disclosure gap hold below Verified.
The Vyvata score's Evidence dimension measures the quality of published RCT support for a product's active ingredients at the label dose. Our source hierarchy: double-blind RCTs in MEDLINE-indexed journals > single-blind RCTs > open-label trials > observational studies > mechanism papers > N=1 case studies (anecdotes). Predatory journals and manufacturer-authored studies without independent replication are weighted down.
Product-specific evidence citations for this item are embedded in the analysis text on the "Analysis" tab. For the full framework and evidence hierarchy, see the methodology page.
FAQ data has not been generated for this product yet. See the site FAQ for general questions.
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Every score is set from the published rubric, audit-logged, and rescored whenever new evidence emerges (published trials, updated labels, third-party testing releases). Every vendor is scored on the same criteria — no pay-to-play. See our editorial-independence disclosure for the full policy, including brands with an editorial relationship to this site.

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