Optimum Nutrition
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Berberine
Berberine
No reviews
No reviews
Regular price
$23.79 USD
Regular price
Sale price
$23.79 USD
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The full picture
Everything Vyvata knows about this product — the score, the evidence, the FAQ, and where else to find shopper reviews. No hidden data. Every vendor is scored on the same published rubric — no brand can pay for placement. Read the rubric →
68/100
Standard
Six-dimension breakdown
Evidence
74
Formulation
65
Manufacturing
62
Safety
62
Transparency
65
Sustainability
55
Why this scored 68/100
Straight berberine HCl capsule. Yin 2008 showed berberine 500mg TID was non-inferior to metformin for HbA1c and fasting glucose in T2D; Guo 2016 meta-analysis confirmed the effect. Main limits: ~1% oral bioavailability so the studied 1500mg/day is a lot of capsules; GI side effects common; meaningful CYP3A4 drug interactions. Would move to Verified with berberine HCl % purity (>97%) disclosed and enhanced-absorption forms (dihydroberberine, Berbevis phytosome).
Last scored: Full rubric →
Evidence & sources
The Vyvata score's Evidence dimension measures the quality of published RCT support for a product's active ingredients at the label dose. Our source hierarchy: double-blind RCTs in MEDLINE-indexed journals > single-blind RCTs > open-label trials > observational studies > mechanism papers > N=1 case studies (anecdotes). Predatory journals and manufacturer-authored studies without independent replication are weighted down.
Product-specific evidence citations for this item are embedded in the analysis text on the "Analysis" tab. For the full framework and evidence hierarchy, see the methodology page.
How to read the Evidence dimension
- 80–100: Multiple double-blind RCTs in indexed journals directly testing this product OR the exact ingredients at the exact dose.
- 60–79: Single double-blind RCT + supporting ingredient literature at the studied dose.
- 40–59: Open-label trials + ingredient literature; no product-specific double-blind evidence.
- 20–39: Ingredient literature only; no product-specific trials or trials in predatory venues.
- 0–19: No credible evidence base or unverifiable claims.
Frequently asked questions
Auto-generated from Vyvata's scoring data for this product. For general questions about the store (shipping, returns, wholesale), see the site FAQ.
What is Berberine?
Berberine, categorized under Weight management & metabolic health in the Supplements vertical. It is scored on the Vyvata Scoring Framework — an independent 6-dimension rubric applied uniformly to every product Vyvata lists.
How does Berberine score on the Vyvata rubric?
68/100 overall — Standard tier (50–69 band). Per-dimension breakdown: Evidence 74, Formulation 65, Transparency 65, Manufacturing 62, Safety 62, Sustainability 55. Scored as of 2026-08-24.
Why did Berberine score in the Standard tier?
Straight berberine HCl capsule. Yin 2008 showed berberine 500mg TID was non-inferior to metformin for HbA1c and fasting glucose in T2D; Guo 2016 meta-analysis confirmed the effect. Main limits: ~1% oral bioavailability so the studied 1500mg/day is a lot of capsules; GI side effects common; meaningful CYP3A4 drug interactions. Would move to Verified with berberine HCl % purity (>97%) disclosed and enhanced-absorption forms (dihydroberberine, Berbevis phytosome).
What are the strongest and weakest aspects of this product?
Strongest: Evidence at 74/100 (quality of published RCT support for the active ingredients at the label dose) and Formulation at 65/100 (dose adequacy, bioavailability form, and ingredient redundancy). Weakest: Safety at 62/100 (adverse-event profile, interaction risk, and dose ceiling) and Sustainability at 55/100 (sourcing practices, packaging, and corporate practice). All six dimensions feed the overall Vyvata score; a weakness on any one dimension pulls the overall down proportionally.
Is Berberine third-party tested?
No third-party certifications (NSF, USP, ConsumerLab, or equivalent) were on record at the time of scoring. This affects the Manufacturing dimension score. The manufacturer may test internally or have obtained certification more recently — check the current product label for the most up-to-date information.
What would move Berberine to a higher tier?
Would move to Verified with berberine HCl % purity (>97%) disclosed and enhanced-absorption forms (dihydroberberine, Berbevis phytosome).
Are there higher-scoring alternatives to Berberine?
The top-ranked weight management & metabolic health product in the Vyvata catalog is currently Thorne Berberine Dietary Supplement 1000 mg 60 Capsules at 80/100. See the full ranked list of 218 scored products in this subcategory at https://vyvata.com/pages/best-weight-management-and-metabolic-health-supplements-ranked.
What does the Vyvata score mean?
The Vyvata Scoring Framework rates every listed product 0–100 across six dimensions: Evidence, Formulation, Manufacturing, Safety, Transparency, and Sustainability. Tier bands: Elite 85–100 (top-tier evidence + formulation + manufacturing), Verified 70–84 (strong on most dimensions), Standard 50–69 (solid but with weaknesses called out), Rejected 0–49 (specific failures documented). Rejected products remain listed with reasons. Full methodology at https://vyvata.com/pages/methodology.
Where can I read customer reviews for Berberine?
The Vyvata score measures product integrity against a published rubric, not customer sentiment. For customer reviews and community discussion, search external platforms directly: Amazon (https://www.amazon.com/s?k=Berberine),Google(https://www.google.com/search?q=Berberine+reviews),Reddit(https://www.reddit.com/search/?q=Berberine%20review),andTrustpilot(https://www.trustpilot.com/search?query=Berberine).Vyvatadoesnotaggregate,republish,orlicensethosethird-partyreviews.
Customer reviews
Reviews on other platforms
The Vyvata score measures product integrity against a published rubric, not customer sentiment. Vyvata does not aggregate, republish, or license third-party reviews — the links below open search pages on their respective platforms.
All the data we have on this product
Every VSF-related metafield surfaced verbatim. Nothing hidden. If you spot data that looks wrong, let us know.
- VSF score
- 68 / 100
- Tier
- Standard
- Category
- Supplements
- Subcategory
- weight metabolic health
- Last scored
- Third-party certifications
- None on record at time of scoring
- Vendor
- Swanson Vitamins
- Tags
- Shopify Collective, Swanson Vitamins
Every score is set from the published rubric, audit-logged, and rescored whenever new evidence emerges (published trials, updated labels, third-party testing releases). Every vendor is scored on the same criteria — no pay-to-play. See our editorial-independence disclosure for the full policy, including brands with an editorial relationship to this site.
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