Optimum Nutrition
THE BIOHACKING STANDARD
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Everything Vyvata knows about this product — the score, the evidence, the FAQ, and where else to find shopper reviews. No hidden data. Every vendor is scored on the same published rubric — no brand can pay for placement. Read the rubric →
21st Century is a well-established mass-retail brand with USP-verified capacity, and the explicit 25 mg per-cap disclosure is a real transparency positive — buyers know exactly what they are getting. 25 mg is the lower end of studied efficacy for adults over 40 with low DHEA-S, appropriate as a starter dose or maintenance for women (who metabolize DHEA to testosterone and estradiol at higher rates than men). Same safety considerations apply as any DHEA product: not for under-40s without testing, hormone-sensitive condition contraindications, androgenic side-effect potential. Distributed through a legitimate pharmacy retail channel adds a modest quality signal. Would move to Verified 72+ with explicit 'lab-confirm DHEA-S before use' warning and per-lot third-party assay.
The Vyvata score's Evidence dimension measures the quality of published RCT support for a product's active ingredients at the label dose. Our source hierarchy: double-blind RCTs in MEDLINE-indexed journals > single-blind RCTs > open-label trials > observational studies > mechanism papers > N=1 case studies (anecdotes). Predatory journals and manufacturer-authored studies without independent replication are weighted down.
Product-specific evidence citations for this item are embedded in the analysis text on the "Analysis" tab. For the full framework and evidence hierarchy, see the methodology page.
FAQ data has not been generated for this product yet. See the site FAQ for general questions.
The Vyvata score measures product integrity against a published rubric, not customer sentiment. Vyvata does not aggregate, republish, or license third-party reviews — the links below open search pages on their respective platforms.
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Every score is set from the published rubric, audit-logged, and rescored whenever new evidence emerges (published trials, updated labels, third-party testing releases). Every vendor is scored on the same criteria — no pay-to-play. See our editorial-independence disclosure for the full policy, including brands with an editorial relationship to this site.

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