Optimum Nutrition
THE BIOHACKING STANDARD
Welcome to our store
Couldn't load pickup availability
Everything Vyvata knows about this product — the score, the evidence, the FAQ, and where else to find shopper reviews. No hidden data. Every vendor is scored on the same published rubric — no brand can pay for placement. Read the rubric →
Senna + cascara sagrada are stimulant laxatives with well-documented risks of dependence, electrolyte disturbances, and melanosis coli (FDA warnings; NIH LiverTox for cascara). Not appropriate for a 15-day regimen. 'Detox' framing lacks clinical support.
Auto-fail rule triggered: Unverified disease claim.
The product markets a disease-treatment, -prevention, or -cure claim (memory loss, cardiovascular disease, cancer, etc.) without published double-blind RCT evidence at the label dose to support that claim. Under FDA and FTC guidance this level of claim requires drug-approval standards of evidence. See the full rubric →
The Vyvata score's Evidence dimension measures the quality of published RCT support for a product's active ingredients at the label dose. Our source hierarchy: double-blind RCTs in MEDLINE-indexed journals > single-blind RCTs > open-label trials > observational studies > mechanism papers > N=1 case studies (anecdotes). Predatory journals and manufacturer-authored studies without independent replication are weighted down.
Product-specific evidence citations for this item are embedded in the analysis text on the "Analysis" tab. For the full framework and evidence hierarchy, see the methodology page.
Auto-generated from Vyvata's scoring data for this product. For general questions about the store (shipping, returns, wholesale), see the site FAQ.
15 Day Cleanse | Colon Detox with Natural Laxative for Constipation & Bloating. is a product from Saint Mingiano - Supplements & Wellness Dedicated to Holistic Health, categorized under Gut health & digestive support in the Supplements vertical. It is scored on the Vyvata Scoring Framework — an independent 6-dimension rubric applied uniformly to every product Vyvata lists.
38/100 overall — Rejected tier (0–49 band). Per-dimension breakdown: Manufacturing 50, Sustainability 45, Formulation 42, Transparency 40, Evidence 35, Safety 30. Scored as of 2026-08-24.
Senna + cascara sagrada are stimulant laxatives with well-documented risks of dependence, electrolyte disturbances, and melanosis coli (FDA warnings; NIH LiverTox for cascara). Not appropriate for a 15-day regimen. 'Detox' framing lacks clinical support.
Strongest: Manufacturing at 50/100 (third-party testing, GMP compliance, and facility audit status) and Sustainability at 45/100 (sourcing practices, packaging, and corporate practice). Weakest: Evidence at 35/100 (quality of published RCT support for the active ingredients at the label dose) and Safety at 30/100 (adverse-event profile, interaction risk, and dose ceiling). All six dimensions feed the overall Vyvata score; a weakness on any one dimension pulls the overall down proportionally.
No third-party certifications (NSF, USP, ConsumerLab, or equivalent) were on record at the time of scoring. This affects the Manufacturing dimension score. The manufacturer may test internally or have obtained certification more recently — check the current product label for the most up-to-date information.
This product triggered the Vyvata auto-fail rule "unverified_disease_claim", which places it in the Rejected tier regardless of its scores on other dimensions. See the full explanation above and the methodology page for the current list of auto-fail rules.
The top-ranked gut health & digestive support product in the Vyvata catalog is currently Microbiome Labs MegaSporeBiotic Probiotics for Women & Men at 75/100. See the full ranked list of 316 scored products in this subcategory at https://vyvata.com/pages/best-gut-health-and-digestive-support-supplements-ranked.
The Vyvata Scoring Framework rates every listed product 0–100 across six dimensions: Evidence, Formulation, Manufacturing, Safety, Transparency, and Sustainability. Tier bands: Elite 85–100 (top-tier evidence + formulation + manufacturing), Verified 70–84 (strong on most dimensions), Standard 50–69 (solid but with weaknesses called out), Rejected 0–49 (specific failures documented). Rejected products remain listed with reasons. Full methodology at https://vyvata.com/pages/methodology.
The Vyvata score measures product integrity against a published rubric, not customer sentiment. For customer reviews and community discussion, search external platforms directly: Amazon (https://www.amazon.com/s?k=Saint%20Mingiano%20-%20Supplements%20%26%20Wellness%20Dedicated%20to%20Holistic%20Health%2015%20Day%20Cleanse%20%7C%20Colon%20Detox%20with%20Natural%20Laxative%20),Google(https://www.google.com/search?q=Saint%20Mingiano%20-%20Supplements%20%26%20Wellness%20Dedicated%20to%20Holistic%20Health%2015%20Day%20Cleanse%20%7C%20Colon%20Detox%20with%20Natural%20Laxative%20+reviews),Reddit(https://www.reddit.com/search/?q=Saint%20Mingiano%20-%20Supplements%20%26%20Wellness%20Dedicated%20to%20Holistic%20Health%2015%20Day%20Cleanse%20%7C%20Colon%20Detox%20with%20Natural%20Laxative%20%20review),andTrustpilot(https://www.trustpilot.com/search?query=Saint%20Mingiano%20-%20Supplements%20%26%20Wellness%20Dedicated%20to%20Holistic%20Health%2015%20Day%20Cleanse%20%7C%20Colon%20Detox%20with%20Natural%20Laxative%20).Vyvatadoesnotaggregate,republish,orlicensethosethird-partyreviews.
The Vyvata score measures product integrity against a published rubric, not customer sentiment. Vyvata does not aggregate, republish, or license third-party reviews — the links below open search pages on their respective platforms.
Every VSF-related metafield surfaced verbatim. Nothing hidden. If you spot data that looks wrong, let us know.
unverified_disease_claimEvery score is set from the published rubric, audit-logged, and rescored whenever new evidence emerges (published trials, updated labels, third-party testing releases). Every vendor is scored on the same criteria — no pay-to-play. See our editorial-independence disclosure for the full policy, including brands with an editorial relationship to this site.

Optimum Nutrition
Onnit
WOW MD LLC
Prevagen
Find Your Protocol
A few quick questions about your goals and current concerns. We'll build a tailored protocol — a Basics list of essentials plus a comprehensive Biohackers list — across all Vyvata categories.
No signup required · Your protocol is private to you