Optimum Nutrition
THE BIOHACKING STANDARD
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The 'detox' positioning is an unverified medical claim — the liver, kidneys, gut lining, lymphatic system, and skin already perform detoxification continuously in every healthy person, and no oral supplement has cleared the FDA/EMA evidentiary bar for the general-population claim of 'detoxifying the body.' Cochrane and NIH NCCIH reviews of commercial detox products have consistently concluded that human clinical evidence is absent or of poor methodological quality. Upgraded Formulas is a legitimate biohacker-adjacent brand with credible single-ingredient mineral products elsewhere in its line, but this multi-ingredient blend combines the auto-fail 'detox' claim with a proprietary-blend structure that does not disclose per-constituent milligrams for the botanicals, digestive enzymes, or debloat actives in the formula. The 'debloat' component is the more defensible half — digestive enzymes, ginger, and fennel can genuinely reduce post-prandial bloating short-term — but without per-ingredient dosing that clinical support does not attach to this specific SKU. Auto-failed on unverified_medical_claim for the 'detox' framing. Would move above Standard with a name change (drop 'detox'), full quantitative facts panel, and refocus on the digestive-enzyme/carminative science that does have real support.
The Vyvata score's Evidence dimension measures the quality of published RCT support for a product's active ingredients at the label dose. Our source hierarchy: double-blind RCTs in MEDLINE-indexed journals > single-blind RCTs > open-label trials > observational studies > mechanism papers > N=1 case studies (anecdotes). Predatory journals and manufacturer-authored studies without independent replication are weighted down.
Product-specific evidence citations for this item are embedded in the analysis text on the "Analysis" tab. For the full framework and evidence hierarchy, see the methodology page.
FAQ data has not been generated for this product yet. See the site FAQ for general questions.
The Vyvata score measures product integrity against a published rubric, not customer sentiment. Vyvata does not aggregate, republish, or license third-party reviews — the links below open search pages on their respective platforms.
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Every score is set from the published rubric, audit-logged, and rescored whenever new evidence emerges (published trials, updated labels, third-party testing releases). Every vendor is scored on the same criteria — no pay-to-play. See our editorial-independence disclosure for the full policy, including brands with an editorial relationship to this site.

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