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NusaPure St. John's Wort 20:1 Extract, 300 mg 240 Veggie Capsules (Vegetarian, Non-GMO & Vegan) Bioperine
NusaPure St. John's Wort 20:1 Extract, 300 mg 240 Veggie Capsules (Vegetarian, Non-GMO & Vegan) Bioperine
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Regular price
$27.50 USD
Regular price
Sale price
$27.50 USD
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The full picture
Everything Vyvata knows about this product — the score, the evidence, the FAQ, and where else to find shopper reviews. No hidden data. Every vendor is scored on the same published rubric — no brand can pay for placement. Read the rubric →
55/100
Standard
Six-dimension breakdown
Evidence
65
Formulation
60
Manufacturing
52
Safety
55
Transparency
55
Sustainability
45
Why this scored 55/100
St. John's Wort (Hypericum perforatum) 20:1 extract 300 mg. Real evidence for mild-to-moderate depression (Linde 2008 Cochrane review — comparable to SSRIs for mild-moderate cases). Held below Verified by (1) hyperforin standardization (the primary active for antidepressant effect, typically 3-5%) not disclosed; (2) major drug-interaction profile — St. John's Wort is a potent CYP3A4 inducer that reduces effectiveness of oral contraceptives, warfarin, statins, HIV protease inhibitors, immunosuppressants, and many chemotherapy drugs. Under-labeled interaction warnings are a real safety issue; (3) NusaPure budget manufacturing. Would move to Verified 70+ with hyperforin standardization + prominent drug-interaction warning + third-party testing.
Last scored: Full rubric →
Evidence & sources
The Vyvata score's Evidence dimension measures the quality of published RCT support for a product's active ingredients at the label dose. Our source hierarchy: double-blind RCTs in MEDLINE-indexed journals > single-blind RCTs > open-label trials > observational studies > mechanism papers > N=1 case studies (anecdotes). Predatory journals and manufacturer-authored studies without independent replication are weighted down.
Product-specific evidence citations for this item are embedded in the analysis text on the "Analysis" tab. For the full framework and evidence hierarchy, see the methodology page.
How to read the Evidence dimension
- 80–100: Multiple double-blind RCTs in indexed journals directly testing this product OR the exact ingredients at the exact dose.
- 60–79: Single double-blind RCT + supporting ingredient literature at the studied dose.
- 40–59: Open-label trials + ingredient literature; no product-specific double-blind evidence.
- 20–39: Ingredient literature only; no product-specific trials or trials in predatory venues.
- 0–19: No credible evidence base or unverifiable claims.
Frequently asked questions
Auto-generated from Vyvata's scoring data for this product. For general questions about the store (shipping, returns, wholesale), see the site FAQ.
What is NusaPure St. John's Wort 20:1 Extract, 300 mg 240 Veggie Capsules (Vegetarian, Non-GMO & Vegan) Bioperine?
NusaPure St. John's Wort 20:1 Extract, 300 mg 240 Veggie Capsules (Vegetarian, Non-GMO & Vegan) Bioperine is a product from NusaPure, categorized under Stress, mood & mental wellness in the Supplements vertical. It is scored on the Vyvata Scoring Framework — an independent 6-dimension rubric applied uniformly to every product Vyvata lists.
How does NusaPure St. John's Wort 20:1 Extract, 300 mg 240 Veggie Capsules (Vegetarian, Non-GMO & Vegan) Bioperine score on the Vyvata rubric?
55/100 overall — Standard tier (50–69 band). Per-dimension breakdown: Evidence 65, Formulation 60, Safety 55, Transparency 55, Manufacturing 52, Sustainability 45. Scored as of 2026-08-24.
Why did NusaPure St. John's Wort 20:1 Extract, 300 mg 240 Veggie Capsules (Vegetarian, Non-GMO & Vegan) Bioperine score in the Standard tier?
St. John's Wort (Hypericum perforatum) 20:1 extract 300 mg. Real evidence for mild-to-moderate depression (Linde 2008 Cochrane review — comparable to SSRIs for mild-moderate cases). Held below Verified by (1) hyperforin standardization (the primary active for antidepressant effect, typically 3-5%) not disclosed; (2) major drug-interaction profile — St. John's Wort is a potent CYP3A4 inducer that reduces effectiveness of oral contraceptives, warfarin, statins, HIV protease inhibitors, immunosuppressants, and many chemotherapy drugs. Under-labeled interaction warnings are a real safety issue; (3) NusaPure budget manufacturing. Would move to Verified 70+ with hyperforin standardization + prominent drug-interaction warning + third-party testing.
What are the strongest and weakest aspects of this product?
Strongest: Evidence at 65/100 (quality of published RCT support for the active ingredients at the label dose) and Formulation at 60/100 (dose adequacy, bioavailability form, and ingredient redundancy). Weakest: Manufacturing at 52/100 (third-party testing, GMP compliance, and facility audit status) and Sustainability at 45/100 (sourcing practices, packaging, and corporate practice). All six dimensions feed the overall Vyvata score; a weakness on any one dimension pulls the overall down proportionally.
Is NusaPure St. John's Wort 20:1 Extract, 300 mg 240 Veggie Capsules (Vegetarian, Non-GMO & Vegan) Bioperine third-party tested?
No third-party certifications (NSF, USP, ConsumerLab, or equivalent) were on record at the time of scoring. This affects the Manufacturing dimension score. The manufacturer may test internally or have obtained certification more recently — check the current product label for the most up-to-date information.
What would move NusaPure St. John's Wort 20:1 Extract, 300 mg 240 Veggie Capsules (Vegetarian, Non-GMO & Vegan) Bioperine to a higher tier?
Would move to Verified 70+ with hyperforin standardization + prominent drug-interaction warning + third-party testing.
Are there higher-scoring alternatives to NusaPure St. John's Wort 20:1 Extract, 300 mg 240 Veggie Capsules (Vegetarian, Non-GMO & Vegan) Bioperine?
The top-ranked stress, mood & mental wellness product in the Vyvata catalog is currently Momentous Sleep at 77/100. See the full ranked list of 247 scored products in this subcategory at https://vyvata.com/pages/best-stress-mood-and-mental-wellness-supplements-ranked.
What does the Vyvata score mean?
The Vyvata Scoring Framework rates every listed product 0–100 across six dimensions: Evidence, Formulation, Manufacturing, Safety, Transparency, and Sustainability. Tier bands: Elite 85–100 (top-tier evidence + formulation + manufacturing), Verified 70–84 (strong on most dimensions), Standard 50–69 (solid but with weaknesses called out), Rejected 0–49 (specific failures documented). Rejected products remain listed with reasons. Full methodology at https://vyvata.com/pages/methodology.
Where can I read customer reviews for NusaPure St. John's Wort 20:1 Extract, 300 mg 240 Veggie Capsules (Vegetarian, Non-GMO & Vegan) Bioperine?
The Vyvata score measures product integrity against a published rubric, not customer sentiment. For customer reviews and community discussion, search external platforms directly: Amazon (https://www.amazon.com/s?k=NusaPure%20NusaPure%20St.%20John's%20Wort%2020%3A1%20Extract%2C%20300%20mg%20240%20Veggie%20Capsules%20(Vegetarian%2C%20Non-GMO%20%26%20Vegan)%20Bioperine),Google(https://www.google.com/search?q=NusaPure%20NusaPure%20St.%20John's%20Wort%2020%3A1%20Extract%2C%20300%20mg%20240%20Veggie%20Capsules%20(Vegetarian%2C%20Non-GMO%20%26%20Vegan)%20Bioperine+reviews),Reddit(https://www.reddit.com/search/?q=NusaPure%20NusaPure%20St.%20John's%20Wort%2020%3A1%20Extract%2C%20300%20mg%20240%20Veggie%20Capsules%20(Vegetarian%2C%20Non-GMO%20%26%20Vegan)%20Bioperine%20review),andTrustpilot(https://www.trustpilot.com/search?query=NusaPure%20NusaPure%20St.%20John's%20Wort%2020%3A1%20Extract%2C%20300%20mg%20240%20Veggie%20Capsules%20(Vegetarian%2C%20Non-GMO%20%26%20Vegan)%20Bioperine).Vyvatadoesnotaggregate,republish,orlicensethosethird-partyreviews.
Customer reviews
Reviews on other platforms
The Vyvata score measures product integrity against a published rubric, not customer sentiment. Vyvata does not aggregate, republish, or license third-party reviews — the links below open search pages on their respective platforms.
All the data we have on this product
Every VSF-related metafield surfaced verbatim. Nothing hidden. If you spot data that looks wrong, let us know.
- VSF score
- 55 / 100
- Tier
- Standard
- Category
- Supplements
- Subcategory
- stress mood mental
- Last scored
- Third-party certifications
- None on record at time of scoring
- Vendor
- NusaPure
- Tags
- NusaPure, Shopify Collective
Every score is set from the published rubric, audit-logged, and rescored whenever new evidence emerges (published trials, updated labels, third-party testing releases). Every vendor is scored on the same criteria — no pay-to-play. See our editorial-independence disclosure for the full policy, including brands with an editorial relationship to this site.
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