Optimum Nutrition
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Diosmin (a flavonoid glycoside from citrus) has strong evidence for chronic venous insufficiency and hemorrhoids, particularly in micronized purified flavonoid fraction (Daflon 500) at 900mg diosmin + 100mg hesperidin/day — a Cochrane-supported protocol. 1000mg per serving is within therapeutic range if the ratio approximates 90% diosmin / 10% hesperidin. Micronization status not disclosed and matters heavily for absorption. Citrus aurantium mention is neutral — bitter orange contains synephrine, which has cardiovascular safety concerns and should be quantified separately. Would move to Verified 70+ with micronized-fraction spec and disclosed diosmin:hesperidin ratio.
The Vyvata score's Evidence dimension measures the quality of published RCT support for a product's active ingredients at the label dose. Our source hierarchy: double-blind RCTs in MEDLINE-indexed journals > single-blind RCTs > open-label trials > observational studies > mechanism papers > N=1 case studies (anecdotes). Predatory journals and manufacturer-authored studies without independent replication are weighted down.
Product-specific evidence citations for this item are embedded in the analysis text on the "Analysis" tab. For the full framework and evidence hierarchy, see the methodology page.
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NusaPure Diosmin Complex 1,000mg per Serving 180 Veggie Caps (Non-GMO, Vegan) Citrus Aurantium is a product from NusaPure, categorized under Cardiovascular & heart health in the Supplements vertical. It is scored on the Vyvata Scoring Framework — an independent 6-dimension rubric applied uniformly to every product Vyvata lists.
65/100 overall — Standard tier (50–69 band). Per-dimension breakdown: Evidence 72, Formulation 65, Safety 62, Transparency 62, Manufacturing 55, Sustainability 48. Scored as of 2026-08-24.
Diosmin (a flavonoid glycoside from citrus) has strong evidence for chronic venous insufficiency and hemorrhoids, particularly in micronized purified flavonoid fraction (Daflon 500) at 900mg diosmin + 100mg hesperidin/day — a Cochrane-supported protocol. 1000mg per serving is within therapeutic range if the ratio approximates 90% diosmin / 10% hesperidin. Micronization status not disclosed and matters heavily for absorption. Citrus aurantium mention is neutral — bitter orange contains synephrine, which has cardiovascular safety concerns and should be quantified separately. Would move to Verified 70+ with micronized-fraction spec and disclosed diosmin:hesperidin ratio.
Strongest: Evidence at 72/100 (quality of published RCT support for the active ingredients at the label dose) and Formulation at 65/100 (dose adequacy, bioavailability form, and ingredient redundancy). Weakest: Manufacturing at 55/100 (third-party testing, GMP compliance, and facility audit status) and Sustainability at 48/100 (sourcing practices, packaging, and corporate practice). All six dimensions feed the overall Vyvata score; a weakness on any one dimension pulls the overall down proportionally.
No third-party certifications (NSF, USP, ConsumerLab, or equivalent) were on record at the time of scoring. This affects the Manufacturing dimension score. The manufacturer may test internally or have obtained certification more recently — check the current product label for the most up-to-date information.
Would move to Verified 70+ with micronized-fraction spec and disclosed diosmin:hesperidin ratio.
The top-ranked cardiovascular & heart health product in the Vyvata catalog is currently Nordic Naturals Ultimate Omega 2X – High-Potency Fish Oil | 2150 mg EPA & DHA | Lemon Flavor, 120 Softgels at 87/100. See the full ranked list of 345 scored products in this subcategory at https://vyvata.com/pages/best-cardiovascular-and-heart-health-supplements-ranked.
The Vyvata Scoring Framework rates every listed product 0–100 across six dimensions: Evidence, Formulation, Manufacturing, Safety, Transparency, and Sustainability. Tier bands: Elite 85–100 (top-tier evidence + formulation + manufacturing), Verified 70–84 (strong on most dimensions), Standard 50–69 (solid but with weaknesses called out), Rejected 0–49 (specific failures documented). Rejected products remain listed with reasons. Full methodology at https://vyvata.com/pages/methodology.
The Vyvata score measures product integrity against a published rubric, not customer sentiment. For customer reviews and community discussion, search external platforms directly: Amazon (https://www.amazon.com/s?k=NusaPure%20NusaPure%20Diosmin%20Complex%201%2C000mg%20per%20Serving%20180%20Veggie%20Caps%20(Non-GMO%2C%20Vegan)%20Citrus%20Aurantium),Google(https://www.google.com/search?q=NusaPure%20NusaPure%20Diosmin%20Complex%201%2C000mg%20per%20Serving%20180%20Veggie%20Caps%20(Non-GMO%2C%20Vegan)%20Citrus%20Aurantium+reviews),Reddit(https://www.reddit.com/search/?q=NusaPure%20NusaPure%20Diosmin%20Complex%201%2C000mg%20per%20Serving%20180%20Veggie%20Caps%20(Non-GMO%2C%20Vegan)%20Citrus%20Aurantium%20review),andTrustpilot(https://www.trustpilot.com/search?query=NusaPure%20NusaPure%20Diosmin%20Complex%201%2C000mg%20per%20Serving%20180%20Veggie%20Caps%20(Non-GMO%2C%20Vegan)%20Citrus%20Aurantium).Vyvatadoesnotaggregate,republish,orlicensethosethird-partyreviews.
The Vyvata score measures product integrity against a published rubric, not customer sentiment. Vyvata does not aggregate, republish, or license third-party reviews — the links below open search pages on their respective platforms.
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Every score is set from the published rubric, audit-logged, and rescored whenever new evidence emerges (published trials, updated labels, third-party testing releases). Every vendor is scored on the same criteria — no pay-to-play. See our editorial-independence disclosure for the full policy, including brands with an editorial relationship to this site.

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